ArticleBrain imaging and behavior2019
Altered structural brain connectivity involving the dorsal and ventral language pathways in 16p11.2 deletion syndrome.
Article in Brain imaging and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Microstructural alterations of the trigeminal ganglion in chronic ocular surface pain patients: A diffusion MRI study.NeuroImage · 2025Article
- Structural pathways related to the subventricular zone are decreased in volume with altered microstructure in young adult males with autism spectrum disorder.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Language Profiles of School-Age Children With 16p11.2 Copy Number Variants in a Clinically Ascertained Cohort.Journal of speech, language, and hearing research : JSLHR · 2024Article
- The pleiotropic spectrum of proximal 16p11.2 CNVs.American journal of human genetics · 2024Review
- Impulsive and compulsive reading comprehension in the prison population.BMC psychiatry · 2024Article
- Negative versus withdrawn maternal behavior: Differential associations with infant gray and white matter during the first 2 years of life.Human brain mapping · 2023Article
- 16p11.2 deletion mice exhibit compromised fronto-temporal connectivity, GABAergic dysfunction, and enhanced attentional ability.Communications biology · 2023Article
- Neuroimaging Findings in Patients withMolecular syndromology · 2021Article
- Male-specific alterations in structure of isolation call sequences of mouse pups with 16p11.2 deletion.Genes, brain, and behavior · 2020Article
- Altered White Matter Organization in the TUBB3 E410K Syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Altered White Matter Connectivity Associated with Intergyral Brain Disorganization in Hemiplegic Cerebral Palsy.Neuroscience · 2019Article
- Brain Characteristics Noted Prior to and Following Cranial Orthotic Treatment.Child neurology openArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Copy number variants at the chromosomal locus 16p11.2 contribute to neurodevelopmental disorders such as autism spectrum disorders, epilepsy, schizophrenia, and language and articulation disorders. Here, we provide detailed findings on the disrupted structural brain connectivity in 16p11.2 deletion syndrome (patients: N = 21, age range: 8-16 years; typically developing (TD) controls: 18, 9-16 years) using structural and diffusion MRI. We performed global short-, middle-, long-range, and interhemispheric connectivity analysis in the whole brain using gyral topology-based cortical parcellation. Using region of interest analysis, we studied bilateral dorsal (3 segments of arcuate fasciculus (AF)) and ventral (inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus (ILF), uncinate fasciculus (UF)) language pathways. Our results showed significantly increased axial (AD) and radial (RD) diffusivities in bilateral anterior AF, decreased volume for left long AF, increased mean diffusivity (MD) and RD for right long AF, and increased AD for bilateral UF in the 16p11.2 deletion group in the absence of significant abnormalities in the whole-brain gyral and interhemispheric connectivity. The selective involvement of the language networks may aid in understanding effects of altered white matter connectivity on neurodevelopmental outcomes in 16p11.2 deletion.
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