Evidence map›Paper›PMID 29629340›Full record

ArticleFrontiers in cellular and infection microbiology2018

Enterokinase Enhances Influenza A Virus Infection by Activating Trypsinogen in Human Cell Lines.

Hideki Hayashi, Yoshinao Kubo, Mai Izumida, Etsuhisa Takahashi, Hiroshi Kido, Ko Sato, Mutsuo Yamaya, Hidekazu Nishimura, Kou Nakayama, Toshifumi Matsuyama

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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  9. Novel Compound HeterozygousFrontiers in genetics · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Hideki HayashiMedical University Research Administrator, Nagasaki University School of Medicine, Nagasaki, Japan.
Yoshinao KuboProgram for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Mai IzumidaDepartment of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Etsuhisa TakahashiDivision of Enzyme Chemistry, Institute for Enzyme Research, Tokushima University, Tokushima, Japan.
Hiroshi KidoDivision of Enzyme Chemistry, Institute for Enzyme Research, Tokushima University, Tokushima, Japan.
Ko SatoVirus Research Center, Clinical Research Division, Sendai Medical Center, Sendai, Japan.
Mutsuo YamayaDepartment of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hidekazu NishimuraVirus Research Center, Clinical Research Division, Sendai Medical Center, Sendai, Japan.
Kou NakayamaMedical University Research Administrator, Nagasaki University School of Medicine, Nagasaki, Japan.
Toshifumi MatsuyamaDepartment of Cancer Stem Cell Biology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Nagasaki University · JPSendai Medical Center · JPTokushima University · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cleavage and activation of hemagglutinin (HA) by trypsin-like proteases in influenza A virus (IAV) are essential prerequisites for its successful infection and spread. In host cells, some transmembrane serine proteases such as TMPRSS2, TMPRSS4 and HAT, along with plasmin in the bloodstream, have been reported to cleave the HA precursor (HA

Indexed as

Cell LineEnzyme ActivationHemagglutinin Glycoproteins, Influenza VirusHost-Pathogen InteractionsHumansInfluenza A Virus, H1N1 SubtypeInfluenza, HumanProtein Processing, Post-TranslationalSerine EndopeptidasesTrypsinH1N1 virus hemagglutininHemagglutinin Glycoproteins, Influenza VirusPRSS3 protein, humanSerine EndopeptidasesTMPRSS2 protein, humanTrypsinenterokinasegenome structure and functionhemagglutinin processinginfluenza A virustransmembrane serine protease

Identifiers

PMID29629340
PMCPMC5876233
OpenAlexW2792058877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.