ArticleChemical science2018
Design of DNA nanostructure-based interfacial probes for the electrochemical detection of nucleic acids directly in whole blood.
Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 115 citations in OpenAlex.
- Recent Progress in DNA Biosensors: Target-Specific and Structure-Guided Signal Amplification.Biosensors · 2025Review
- Modular DNA origami-based electrochemical detection of DNA and proteins.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Proximity-Driven DNA Nanosensors.ECS sensors plus · 2023Article
- Methylene-Blue-Encapsulated Metal-Organic-Framework-Based Electrochemical POCT Platform for Multiple Detection of Heavy Metal Ions in Milk.Biosensors · 2023Article
- Affinity-based electrochemical sensors for biomolecular detection in whole blood.Analytical and bioanalytical chemistry · 2023Review
- Biomolecular sensors for advanced physiological monitoring.Nature reviews bioengineering · 2023Review
- Functional Xeno Nucleic Acids for Biomedical Application.Chemical research in Chinese universities · 2022Review
- Bioinspired superwettable electrodes towards electrochemical biosensing.Chemical science · 2022Review
- The biological applications of DNA nanomaterials: current challenges and future directions.Signal transduction and targeted therapy · 2021Review
- DNA Transformations for Diagnosis and Therapy.Advanced functional materials · 2021Review
- Conformational Changes of Immobilized Polythymine due to External Stressors Studied with Temperature-Controlled Electrochemical Microdevices.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Radiolabeling and Preliminary Evaluation ofInternational journal of nanomedicine · 2021Article
- Recent Advances in Electrochemical Sensors for the Detection of Biomolecules and Whole Cells.Biomedicines · 2020Review
- Dynamic DNA Assemblies in Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Beyond Sensitive and Selective Electrochemical Biosensors: Towards Continuous, Real-Time, Antibiofouling and Calibration-Free Devices.Sensors (Basel, Switzerland) · 2020Review
- A dual signal amplification strategy combining thermally initiated SI-RAFT polymerization and DNA-templated silver nanoparticles for electrochemical determination of DNA.Mikrochimica acta · 2019Article
- Bioapplications of DNA nanotechnology at the solid-liquid interface.Chemical Society reviews · 2019Review
- Click DNA cycling in combination with gold nanoparticles loaded with quadruplex DNA motifs enable sensitive electrochemical quantitation of the tuberculosis-associated biomarker CFP-10 in sputum.Mikrochimica acta · 2019Article
- Photoelectrochemical determination of ractopamine based on inner filter effect between gold nanoparticles and graphitic carbon nitride-copper(II) polyphthalocyanine coupled with 3D DNA stabilizer.Mikrochimica acta · 2019Article
- DNA Nanotechnology for Cancer Diagnosis and Therapy.International journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we report a robust and sensitive DNA nanostructure-based electrochemical (E-nanoDNA) sensor that utilizes tetrahedral DNA nanostructures (TDNs) as an interfacial probe to detect biomolecules in a single-step procedure. In this study, we have firstly demonstrated that the use of TDNs can significantly suppress electrochemical background signals compared to traditional linear DNA probes upon introduction of base mismatches in the edges of TDNs. After further optimization of the two functional strands in the TDNs, quantitative, one-step detection of DNA can be achieved in the picomolar range in less than 10 min, and directly in complex media. Moreover, the baseline drift of this biosensor can be greatly decreased even after several hours in flowing whole blood
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.