Evidence map›Paper›PMID 29629102›Full record

ArticleChemical science2018

Scalable thioarylation of unprotected peptides and biomolecules under Ni/photoredox catalysis.

Brandon A Vara, Xingpin Li, Simon Berritt, Christopher R Walters, E James Petersson, Gary A Molander

Abstract read
In one paragraph

Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Functionalization of Peptides via Radical Arylation.Chembiochem : a European journal of chemical biology · 2026
    Review
  2. Article
  3. C─S Bond Formation of Aryl Germanes.Angewandte Chemie (International ed. in English) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Radical approaches to C-S bonds.Nature reviews. Chemistry · 2023
    Review
  9. Article
  10. Article
  11. Advancement in Organic Synthesis through High Throughput Experimentation.Chemistry methods : new approaches to solving problems in chemistry · 2021
    Article
  12. An Organometallic Strategy for Cysteine Borylation.Journal of the American Chemical Society · 2021
    Article
  13. Review
  14. DeaminativeChemical science · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Targeting Tryptophan for Tagging Through Photo-induced Electron Transfer.Synlett : accounts and rapid communications in synthetic organic chemistry · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brandon A VaraRoy and Diana Vagelos Laboratories , Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , USA . Email: gmolandr@sas.upenn.edu.ORCID 0000-0002-5029-4911
Xingpin LiRoy and Diana Vagelos Laboratories , Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , USA . Email: gmolandr@sas.upenn.edu.ORCID 0000-0002-6396-2077
Simon BerrittRoy and Diana Vagelos Laboratories , Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , USA . Email: gmolandr@sas.upenn.edu.ORCID 0000-0001-5572-6771
Christopher R WaltersRoy and Diana Vagelos Laboratories , Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , USA . Email: gmolandr@sas.upenn.edu.ORCID 0000-0003-2938-6034
E James PeterssonRoy and Diana Vagelos Laboratories , Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , USA . Email: gmolandr@sas.upenn.edu.ORCID 0000-0003-3854-9210
Gary A MolanderRoy and Diana Vagelos Laboratories , Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , USA . Email: gmolandr@sas.upenn.edu.ORCID 0000-0002-9114-5584

Funding

STRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008275 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI WAND, A. JOSHUA · 1988 to 2018
$6.0M
A Novel Mechanistic Paradigm for Cross-CouplingR01GM113878 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MOLANDER, GARY A · 2015 to 2018
$1.5M
Purchase of a Mass Directed Liquid ChromatographS10OD011980 · OD · UNIVERSITY OF PENNSYLVANIA · PI KOZLOWSKI, MARISA C · 2012 to 2012
$372k
NIGMS NIH HHS R01 GM113878NIGMS NIH HHS T32 GM008275NIH HHS S10 OD011980
6 · The paper itself

Abstract

Site-specific functionalization of unprotected native peptides and biomolecules remains a useful transformation in synthetic design and chemical biology, yet until recently, advancements in transition metal-catalyzed methods, which have prevailed in organic synthesis, have been relatively ineffective when applied to large and structurally complex biomolecules. Here, the mechanistically distinct, Ni/photoredox-catalyzed arylation of unprotected, native thiols (

Identifiers

PMID29629102
PMCPMC5868321

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.