ArticleChemical science2018
Construction of an autonomously concatenated hybridization chain reaction for signal amplification and intracellular imaging.
Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 170 citations in OpenAlex.
- The Trend of Nonenzymatic Nucleic Acid Amplification: Strategies and Diagnostic Application.Precision chemistry · 2025Review
- Recent advances in cascade isothermal amplification techniques for ultra-sensitive nucleic acid detection.Talanta · 2023Review
- The compact integration of a cascaded HCR circuit for highly reliable cancer cell discrimination.Chemical science · 2023Article
- Recent progress in the development of DNA-based biosensors integrated with hybridization chain reaction or catalytic hairpin assembly.Frontiers in chemistry · 2023Review
- Click Chemistry Actuated Exponential Amplification Reaction Assisted CRISPR-Cas12a for the Electrochemical Detection of MicroRNAs.ACS omega · 2022Article
- Monitoring and modulating a catalytic hybridization circuit for self-adaptive bioorthogonal DNA assembly.Chemical science · 2022Article
- Niosome-Assisted Delivery of DNA Fluorescent Probe with Optimized Strand Displacement for Intracellular MicroRNA21 Imaging.Biosensors · 2022Article
- Light Scattering Technology-Combined Ligation-Dependent Loop-Mediated Isothermal Amplification (LL-LAMP) for Sensitive Detection of RNA.ACS omega · 2022Article
- Enhancing cell membrane phase separation for inhibiting cancer metastasis with a stimuli-responsive DNA nanodevice.Chemical science · 2022Article
- Coupling nucleic acid circuitry with the CRISPR-Cas12a system for universal and signal-on detection.RSC advances · 2022Article
- Bioorthogonal regulation of DNA circuits for smart intracellular microRNA imaging.Chemical science · 2021Article
- Intelligent demethylase-driven DNAzyme sensor for highly reliable metal-ion imaging in living cells.Chemical science · 2021Article
- Mini review: Enzyme-based DNA synthesis and selective retrieval for data storage.Computational and structural biotechnology journal · 2021Review
- Label-free and self-assembled fluorescent DNA nanopompom for determination of miRNA-21.Mikrochimica acta · 2020Article
- Rolling circle amplification-driven encoding of different fluorescent molecules for simultaneous detection of multiple DNA repair enzymes at the single-molecule level.Chemical science · 2020Article
- A proteinase-free DNA replication machinery for in vitro and in vivo amplified MicroRNA imaging.Nucleic acids research · 2020Article
- Combined microRNA and mRNA detection in mammalian retinas by in situ hybridization chain reaction.Scientific reports · 2020Article
- Single-molecule dynamic DNA junctions for engineering robust molecular switches.Chemical science · 2019Article
- A DNAzyme-amplified DNA circuit for highly accurate microRNA detection and intracellular imaging.Chemical science · 2019Article
- Single-step multivalent capture assay for nucleic acid detection with dual-affinity regulation using mutation inhibition and allosteric activation.Chemical science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomolecular self-assembly has spurred substantial research efforts for the development of low-cost point-of-care diagnostics. Herein, we introduce an isothermal enzyme-free concatenated hybridization chain reaction (C-HCR), in which the output of the upstream hybridization chain reaction (HCR-1) layer acts as an intermediate input to activate the downstream hybridization chain reaction (HCR-2) layer. The initiator motivates HCR-1 through the autonomous cross-opening of two functional DNA hairpins, yielding polymeric dsDNA nanowires composed of numerous tandem triggers
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.