ArticleKorean journal of family medicine2018
Lower Levels of Serum Adiponectin and the T Allele of rs1501299 of the
Article in Korean journal of family medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Comprehensive Overview of Common Polymorphic Variants in Genes Related to Polycystic Ovary Syndrome.Reproductive sciences (Thousand Oaks, Calif.) · 2021Pooled it
- Effects of ADIPOQ polymorphisms on PCOS risk: a meta-analysis.Reproductive biology and endocrinology : RB&E · 2018Pooled it
- Article
- Review
- Identification of Interactive Genetic Loci Linked to Insulin Resistance in Metabolic Syndrome-An Update.Medicina (Kaunas, Lithuania) · 2025Review
- Adiponectin gene polymorphisms rs1501299 and rs17300539 are not associated with polycystic ovary syndrome.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Serum Leptin Receptor and the rs1137101 Variant of theBiomolecules · 2023Article
- Article
- Association of vitamin D levels and polymorphisms in vitamin D receptor with type 2 diabetes mellitus.Biomedical reports · 2023Article
- Genetic variation in the ADIPOQ gene and serum adiponectin increase the risk of bladder cancer.Journal of applied biomedicine · 2022Article
- Association of maternal dietary habits and ADIPOQ gene polymorphisms with the risk of congenital heart defects in offspring: a hospital-based case-control study.European journal of clinical nutrition · 2022Article
- Single Nucleotide Polymorphism in theBioMed research international · 2022Article
- Pathophysiologic Mechanisms of Insulin Secretion and Signaling-Related Genes in Etiology of Polycystic Ovary Syndrome.Genetics research · 2021Review
- Mechanisms of Adiponectin Action in Fertility: An Overview from Gametogenesis to Gestation in Humans and Animal Models in Normal and Pathological Conditions.International journal of molecular sciences · 2019Review
- Serum homocysteine is associated with polycystic ovarian syndrome in Jordan.Biomedical reports · 2018Article
- Association of Adiponectin and rs1501299 of theBiomolecules · 2018Article
- Correction: Lower Levels of Serum Adiponectin and the T Allele of rs1501299 of theKorean journal of family medicine · 2018Article
- Association of Gene Polymorphisms with Polycystic Ovary Syndrome: A Meta-analysis.Gynecology and minimally invasive therapyArticle
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolycystic ovary syndrome (PCOS) is a common reproductive disorder. Obesity, which is linked with lower adiponectin levels, increases a woman's risk of developing PCOS; however, the association between adiponectin and PCOS is controversial. Adiponectin levels could be affected by single nucleotide polymorphisms (SNPs) in the
methodsOne hundred and fifty-four women with PCOS and 149 age- and body mass index-matched normally menstruating controls were recruited. Serum adiponectin levels were measured using enzyme-linked immunosorbent assay. Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism analysis.
resultsSerum adiponectin levels were significantly lower (P=0.0064) in PCOS women and rs1501299 (+276 G/T) genotype distributions were significantly different (P=0.01) between them and normally menstruating women. Multivariate analysis revealed that adiponectin levels remained significantly lower in PCOS women (P=0.001; odds ratio [OR], 0.9; 95% confidence interval [CI], 0.84-0.96). The GT genotype of rs1501299 increased the risk of PCOS (P<0.001; OR, 5.46; 95% CI, 2.42-12.33) and increased the risk of PCOS by three-fold (P<0.001; OR, 3.00; 95% CI, 1.36-6.60) relative to the TT genotype. The GG genotype increased the risk of PCOS as well (P<0.001; OR, 3:00; 95% CI, 1.36-6.60).
conclusionPCOS is associated with lower serum adiponectin levels independent of age and body mass index. The T allele of the rs1501299 (+276 G/T) SNP of the
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