ArticleNutrition research and practice2018
Reactive oxygen species-dependent apoptosis induction by water extract of
Article in Nutrition research and practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Chemopreventive effects of Xiang Sha Liu Jun Zi Tang on paclitaxel-induced leucopenia and neuropathy in animals.Frontiers in pharmacology · 2023Article
- Organic Acid-Catalyzed Subcritical Water Hydrolysis of ImmatureFoods (Basel, Switzerland) · 2021Article
- Chloroform extract ofMolecular medicine reports · 2021Article
- Article
- Extraction of flavanones from immature Citrus unshiu pomace: process optimization and antioxidant evaluation.Scientific reports · 2020Article
- Semi-Continuous Subcritical Water Extraction of Flavonoids fromAntioxidants (Basel, Switzerland) · 2020Article
- Honokiol ameliorates oxidative stress-induced DNA damage and apoptosis of c2c12 myoblasts by ROS generation and mitochondrial pathway.Animal cells and systems · 2020Article
- Citrus unshiu peel suppress the metastatic potential of murine melanoma B16F10 cells in vitro and in vivo.Phytotherapy research : PTR · 2019Article
- Antagonistic Effect of Cuscuta chinensis on a Rat Model with Unilateral Cryptorchidism.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Protective Effects of Nargenicin A1 against Tacrolimus-Induced Oxidative Stress in Hirame Natural Embryo Cells.International journal of environmental research and public health · 2019Article
- RETRACTED: Protective Effects of Fermented Oyster Extract against RANKL-Induced Osteoclastogenesis through Scavenging ROS Generation in RAW 264.7 Cells.International journal of molecular sciences · 2019Article
- Mitochondrial functions and melatonin: a tour of the reproductive cancers.Cellular and molecular life sciences : CMLS · 2019Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesAlthough several recent studies have reported the anti-cancer effects of extracts or components of MATERIALS/
methodsCytotoxicity was evaluated using the MTT assay. Apoptosis was detected using DAPI staining and flow cytometry analyses. Mitochondrial membrane potential, reactive oxygen species (ROS) assay, caspase activity and Western blotting were used to confirm the basis of apoptosis.
resultsThe results indicated that WECU-induced apoptosis was related to the activation of caspase-8, and -9, representative initiator caspases of extrinsic and intrinsic apoptosis pathways, respectively, and caspase-3 accompanied by proteolytic degradation of poly(ADP-ribose) polymerase and down-regulation of the inhibitors of apoptosis protein family members. WECU also increased the pro-apoptotic BAX to anti-apoptotic BCL-2 ratio, loss of mitochondrial membrane potential and cytochrome c release from mitochondria to cytoplasm. Furthermore, WECU provoked the generation of ROS, but the reduction of cell viability and induction of apoptosis by WECU were prevented when ROS production was blocked by antioxidant N-acetyl cysteine.
conclusionsThese results suggest that WECU suppressed proliferation of MDA-MB-231 cells by activating extrinsic and intrinsic apoptosis pathways in a ROS-dependent manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.