ArticleJournal of breast cancer2018
Clinical Characteristics and Prognosis Associated with Multiple Primary Cancers in Breast Cancer Patients.
Article in Journal of breast cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 28 citations in OpenAlex.
- The risk and prognosis factors of second primary malignancies in hepatocellular carcinoma survivors.Discover oncology · 2026Article
- Multiple primary malignant neoplasms and long-term survival: A case report.Oncology letters · 2025Article
- Multiple Primary Cancers as an Independent Criterion for Germline Testing: Comparison with Guideline-Based Criteria.Journal of clinical medicine · 2025Article
- Breast cancer as the first primary malignancy: clinical pathological characteristics of common cancer combinations.Discover oncology · 2025Review
- Rare comorbidity of colon cancer, hepatic malignant mesothelioma, and abdominal Ewing's sarcoma: a case report.Frontiers in oncology · 2025Article
- Characteristics and survival analysis of breast cancer survivors with metachronous double primary cancers: a retrospective cohort study.Translational cancer research · 2023Article
- Risk and prognosis of secondary esophagus cancer after radiotherapy for breast cancer.Scientific reports · 2023Article
- Synchronous multiple primary malignant neoplasms in breast, kidney, and bilateral thyroid: A case report.World journal of clinical cases · 2023Article
- Malignant fibrous histiocytoma of the axilla with breast cancer: A case report.World journal of clinical cases · 2022Article
- Case report: Quadruple primary malignant neoplasms including esophageal, ureteral, and lung in an elderly male.Open life sciences · 2022Article
- Immunological significance of prognostic markers for breast cancer based on alternative splicing.American journal of translational research · 2022Article
- Article
- Common Multiple Primary Cancers Associated With Breast and Gynecologic Cancers and Their Risk Factors, Pathogenesis, Treatment and Prognosis: A Review.Frontiers in oncology · 2022Review
- Nonmetastatic breast cancer patients subsequently developing second primary malignancy: A population-based study.Cancer medicine · 2021Article
- Survival of women diagnosed with breast cancer and who have survived a previous cancer.Breast cancer research and treatment · 2021Article
- Diagnosis and Individualized Treatment of Three Primary Malignant Tumors: A Case Report.Breast cancer (Dove Medical Press) · 2021Article
- Survival and chemotherapy-related risk of second primary malignancy in breast cancer patients: a SEER-based study.International journal of clinical oncology · 2019Article
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBreast cancer is one of the most common malignancies worldwide and the second most common cancer among Korean women. The prognosis of breast cancer is poor in patients with other primary cancers. However, there have been few clinical studies regarding this issue. Therefore, we analyzed the characteristics and prognosis of patients with breast cancer with multiple primary cancers (MPCs).
methodsData from the Korean Breast Cancer Society Registry were analyzed. Data from enrolled patients who underwent surgery for breast cancer were analyzed for differences in prognosis dependent on the presence of MPCs, and which MPC characteristics affected their prognosis.
resultsAmong the 41,841 patients analyzed, 913 patients were found to have MPCs, accounting for 950 total MPCs. There was a significant difference in survival rates between the breast cancer only group and the MPC group. The 5-year survival rates were 93.6% and 86.7% and the 10-year survival rates were 87.5% and 70.4%, respectively. Among the 913 patients with MPCs, patients with two or more MPCs had significantly worse prognoses than patients with a single MPC. With respect to the time interval between breast cancer and MPC occurrence, patients with a 5-year or greater interval had significantly better prognoses than patients with less than 1 year between occurrences. Among MPCs, thyroid cancer was the most common primary cancer. However, this type was not related to the prognosis of breast cancer. Gynecologic cancer, colorectal cancer, upper gastrointestinal cancer, and lung cancer were related to breast cancer prognosis.
conclusionMPCs were a poor prognostic factor for patients with breast cancer. Two or more MPCs and a shorter time interval between occurrences were worse prognostic factors. Although MPCs were a poor prognostic factor, thyroid cancer did not affect the prognosis of patients with breast cancer.
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