ArticleFrontiers in pharmacology2018
Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity.
Article in Frontiers in pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 78 citations in OpenAlex.
- Article
- Article
- Selenium Ameliorates Acetaminophen-Induced Oxidative Stress via MAPK and Nrf2 Pathways in Mice.Biological trace element research · 2024Article
- Article
- Network pharmacology and experimental verification of the mechanism of licochalcone A againstFrontiers in microbiology · 2024Article
- The Protective Effect and Mechanism of a Phytochemical Extract from the Wild Vegetable Shutou (Foods (Basel, Switzerland) · 2023Article
- Hepatoprotective effect of taxifolin on cyclophosphamide-induced oxidative stress, inflammation, and apoptosis in mice: Involvement of Nrf2/HO-1 signaling.Biomolecules & biomedicine · 2023Article
- The hepatoprotective effect of Sophora viciifolia fruit extract against acetaminophen-induced liver injury in mice.Journal of applied biomedicine · 2023Article
- Hepatoprotective Effects of Radish (Nutrients · 2022Article
- Punicalagin Protects against the Development of Methotrexate-Induced Hepatotoxicity in Mice via Activating Nrf2 Signaling and Decreasing Oxidative Stress, Inflammation, and Cell Death.International journal of molecular sciences · 2022Article
- Gastrodin Alleviates Acetaminophen-Induced Liver Injury in a Mouse Model Through Inhibiting MAPK and Enhancing Nrf2 Pathways.Inflammation · 2022Article
- Natural-like Chalcones with Antitumor Activity on Human MG63 Osteosarcoma Cells.Molecules (Basel, Switzerland) · 2022Article
- Pyrroloquinoline quinone ameliorates liver injury in mice induced by cyclophosphamide.Environmental science and pollution research international · 2022Article
- Upregulation of microRNA-125b-5p alleviates acute liver failure by regulating the Keap1/Nrf2/HO-1 pathway.Frontiers in immunology · 2022Article
- Mechanism of drug-induced liver injury and hepatoprotective effects of natural drugs.Chinese medicine · 2021Review
- Licochalcone A activation of glycolysis pathway has an anti-aging effect on human adipose stem cells.Aging · 2021Article
- Hepatoprotective effects of phytochemicals berberine and umbelliferone against methotrexate-induced hepatic intoxication: experimental studies and in silico evidence.Environmental science and pollution research international · 2021Article
- Anti-Inflammatory Effect of Licochalcone A via Regulation of ORAI1 and KInternational journal of molecular sciences · 2021Article
- Rutaecarpine Protects against Acetaminophen-Induced Acute Liver Injury in Mice by Activating Antioxidant Enzymes.Antioxidants (Basel, Switzerland) · 2021Article
- The Potential Application of Chinese Medicine in Liver Diseases: A New Opportunity.Frontiers in pharmacology · 2021Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetaminophen (APAP) overdose-induced fatal hepatotoxicity is majorly characterized by overwhelmingly increased oxidative stress while enhanced nuclear factor-erythroid 2-related factor 2 (Nrf2) is involved in prevention of hepatotoxicity. Although Licochalcone A (Lico A) upregulates Nrf2 signaling pathway against oxidative stress-triggered cell injury, whether it could protect from APAP-induced hepatotoxicity by directly inducing Nrf2 activation is still poorly elucidated. This study aims to explore the protective effect of Lico A against APAP-induced hepatotoxicity and its underlying molecular mechanisms. Our findings indicated that Lico A effectively decreased
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