Evidence map›Paper›PMID 29628776›Full record

ArticleCancer management and research2018

The association between long-term conditions and uptake of population-based screening for colorectal cancer: results from two English cohort studies.

Benjamin Kearns, Jim Chilcott, Clare Relton, Sophie Whyte, Helen Buckley Woods, Claire Nickerson, Amanda Loban

Registry-linked trialAbstract read
In one paragraph

Article in Cancer management and research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02503969 (Exploratory Analysis on the Impact of Morbidities on Colorectal Cancer Screening Uptake), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02503969 completednot on this map

Exploratory Analysis on the Impact of Morbidities on Colorectal Cancer Screening Uptake

TypeobservationalSponsorUniversity of SheffieldRan2015 to 2015Enrolled8,776ConditionsColorectal CancerArmsExposure to having a long-term condition.
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Benjamin KearnsSchool of Health and Related Research, University of Sheffield, Sheffield, UK.
Jim ChilcottSchool of Health and Related Research, University of Sheffield, Sheffield, UK.
Clare ReltonSchool of Health and Related Research, University of Sheffield, Sheffield, UK.
Sophie WhyteSchool of Health and Related Research, University of Sheffield, Sheffield, UK.
Helen Buckley WoodsSchool of Health and Related Research, University of Sheffield, Sheffield, UK.
Claire NickersonCancer Screening Programmes, Public Health England, Sheffield, UK.
Amanda LobanSchool of Health and Related Research, University of Sheffield, Sheffield, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionUptake of screening for colorectal cancer (CRC) can reduce mortality, and population-based screening is offered in England. To date, there is little evidence on the association between having a long-term condition (LTC) and CRC screening uptake. The objective of this study was to examine the association between having an LTC and uptake of CRC screening in England with the guaiac fecal occult blood test, with a particular focus on common mental disorders.

methodsThe study was a preregistered secondary analysis of two cohorts: first, a linked data set between the regional Yorkshire Health Study (YHS) and the National Health Service National Bowel Cancer Screening Program (BCSP, years 2006-2014); second, the national English Longitudinal Study of Ageing (ELSA, years 2014-2015). Individuals eligible for BCSP screening who participated in either the YHS (7,142) or ELSA Wave 7 (4,099) were included. Study registration: ClinicalTrials.gov, number NCT02503969.

resultsIn both the cohorts, diabetes was associated with lower uptake (YHS odds ratio [OR] for non-uptake 1.35, 95% CI 1.03-1.78; ELSA 1.33, 1.03-1.72) and osteoarthritis was associated with increased uptake (YHS 0.75, 0.57-0.99; ELSA 0.76, 0.62-0.93). After controlling for broader determinants of health, there was no evidence of significantly different uptake for individuals with common mental disorders.

conclusionTwo large independent cohorts provided evidence that uptake of CRC screening is lower among individuals with diabetes and higher among individuals with osteoarthritis. Further work should compare barriers and facilitators to screening among individuals with either of these conditions. This study also demonstrates the benefits of data linkage for improving clinical decision-making.

Indexed as

anxietycolorectal cancerdepressionfecal occult blood testpopulation screeninguptake

Identifiers

PMID29628776
PMCPMC5878662

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.