ELECTROMAGNETICALLY INDUCED DISTORTION OF A FIBRIN MATRIX WITH EMBEDDED MICROPARTICLES.

Tyler Scogin, Sumith Yesudasan, Mitchell L R Walker, Rodney D Averett

Open access · bronzeAbstract read

In one paragraph

Article in Journal of mechanics in medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.2field-weighted citation impact, top 46% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Tyler ScoginThe Daniel Guggenheim School of Aerospace Engineering, College of Engineering, Georgia Institute of Technology, 270 Ferst Drive, Atlanta, GA, 30332-0150, USA. High-Power Electric Propulsion Laboratory, Georgia Institute of Technology, Department of Aerospace Engineering, 625 Lambert St NW, Atlanta, GA 30318, USA.

Sumith YesudasanSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, The University of Georgia, 597 D.W. Brooks Drive, Athens, GA 30602, USA.

Mitchell L R WalkerThe Daniel Guggenheim School of Aerospace Engineering, College of Engineering, Georgia Institute of Technology, 270 Ferst Drive, Atlanta, GA, 30332-0150, USA. High-Power Electric Propulsion Laboratory, Georgia Institute of Technology, Department of Aerospace Engineering, 625 Lambert St NW, Atlanta, GA 30318, USA.

Rodney D AverettSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, The University of Georgia, 597 D.W. Brooks Drive, Athens, GA 30602, USA.

University of Georgia · USElectric Propulsion Laboratory (United States) · USGeorgia Institute of Technology · US

Funding

Effects of Diabetes on the Multiscale Mechanical Behavior of Clot StructuresK01HL115486 · NHLBI · UNIVERSITY OF GEORGIA · PI AVERETT, RODNEY D · 2012 to 2016

$697k

NHLBI NIH HHS K01 HL115486

6 · The paper itself

Abstract

Blood clots occur in the human body when they are required to prevent bleeding. In pathological states such as diabetes and sickle cell disease, blood clots can also form undesirably due to hypercoagulable plasma conditions. With the continued effort in developing fibrin therapies for potential life-saving solutions, more mechanical modeling is needed to understand the properties of fibrin structures with inclusions. In this study, a fibrin matrix embedded with magnetic micro particles (MMPs) was subjected to a magnetic field to determine the magnitude of the required force to create plastic deformation within the fibrin clot. Using finite element (FE) analysis, we estimated the magnetic force from an electromagnet at a sample space located approximately 3 cm away from the coil center. This electromagnetic force coupled with gravity was applied on a fibrin mechanical system with MMPs to calculate the stresses and displacements. Using appropriate coil parameters, it was determined that application of a magnetic field of 730 A/m on the fibrin surface was necessary to achieve an electromagnetic force of 36 nN (to engender plastic deformation).

Indexed as

electromagnetic fieldFibrin matrixfinite element analysismagnetic micro-particlesmechanical behavior

Identifiers

PMID29628543

DOI10.1142/S0219519418500161

PMCPMC5886377

OpenAlexW2784500396

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.