Evidence map›Paper›PMID 29628394›Full record

ArticleStem cell reports2018

Interleukin-6 Regulates Adult Neural Stem Cell Numbers during Normal and Abnormal Post-natal Development.

Mekayla A Storer, Denis Gallagher, Michael P Fatt, Jaclin V Simonetta, David R Kaplan, Freda D Miller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  18. Major Depressive Disorder and Gut Microbiota: Role of Physical Exercise.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mekayla A StorerProgram in Neurosciences and Mental Health, Hospital for Sick Children, Toronto M5G 1L7, Canada.
Denis GallagherProgram in Neurosciences and Mental Health, Hospital for Sick Children, Toronto M5G 1L7, Canada.
Michael P FattProgram in Neurosciences and Mental Health, Hospital for Sick Children, Toronto M5G 1L7, Canada; Institute of Medical Science, University of Toronto, Toronto M5G 1A8, Canada.
Jaclin V SimonettaProgram in Neurosciences and Mental Health, Hospital for Sick Children, Toronto M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto M5G 1A8, Canada.
David R KaplanProgram in Neurosciences and Mental Health, Hospital for Sick Children, Toronto M5G 1L7, Canada; Institute of Medical Science, University of Toronto, Toronto M5G 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto M5G 1A8, Canada. Electronic address: dkaplan@sickkids.ca.
Freda D MillerProgram in Neurosciences and Mental Health, Hospital for Sick Children, Toronto M5G 1L7, Canada; Institute of Medical Science, University of Toronto, Toronto M5G 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto M5G 1A8, Canada; Department of Physiology, University of Toronto, Toronto M5G 1A8, Canada. Electronic address: fredam@sickkids.ca.

Funding

CIHR
6 · The paper itself

Abstract

Circulating systemic factors can regulate adult neural stem cell (NSC) biology, but the identity of these circulating cues is still being defined. Here, we have focused on the cytokine interleukin-6 (IL-6), since increased circulating levels of IL-6 are associated with neural pathologies such as autism and bipolar disorder. We show that IL-6 promotes proliferation of post-natal murine forebrain NSCs and that, when the IL-6 receptor is inducibly knocked out in post-natal or adult neural precursors, this causes a long-term decrease in forebrain NSCs. Moreover, a transient circulating surge of IL-6 in perinatal or adult mice causes an acute increase in neural precursor proliferation followed by long-term depletion of adult NSC pools. Thus, IL-6 signaling is both necessary and sufficient for adult NSC self-renewal, and acute perturbations in circulating IL-6, as observed in many pathological situations, have long-lasting effects on the size of adult NSC pools.

Indexed as

Growth and DevelopmentAdult Stem CellsAnimalsAnimals, NewbornCell CountCell ProliferationInterleukin-6Mice, Inbred C57BLNeural Stem CellsNeurogenesisReceptors, Interleukin-6RNA, MessengerTime FactorsInterleukin-6Receptors, Interleukin-6RNA, Messengeradult neurogenesiscirculating stem cell factorsCNS cytokinesinterleukin-6neural stem cellneural stem cell nicheolfactory bulbpostnatal brain developmentstem cell depletion

Identifiers

PMID29628394
PMCPMC5995693

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.