Evidence map›Paper›PMID 29628322›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2018

Vitamin D Status and Depressive Symptoms in Older Adults: A Role for Physical Functioning?

Elisa J de Koning, Liset E M Elstgeest, Hannie C Comijs, Paul Lips, Judith J M Rijnhart, Harm W J van Marwijk, Aartjan T F Beekman, Marjolein Visser, Brenda W J H Penninx, Natasja M van Schoor

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In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Challenging Task of Addressing the Role of Vitamin D in Late-life Depression: Considerations of Measures, Confounders, Mediators, and Moderators.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Elisa J de KoningAmsterdam Public Health Research Institute, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: ej.dekoning@vumc.nl.
Liset E M ElstgeestAmsterdam Public Health Research Institute, Amsterdam, The Netherlands; Department of Health Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Hannie C ComijsAmsterdam Public Health Research Institute, Amsterdam, The Netherlands; Department of Psychiatry, VU University Medical Center / GGZ inGeest, Amsterdam, The Netherlands.
Paul LipsAmsterdam Public Health Research Institute, Amsterdam, The Netherlands; Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands.
Judith J M RijnhartAmsterdam Public Health Research Institute, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands.
Harm W J van MarwijkAmsterdam Public Health Research Institute, Amsterdam, The Netherlands; General Practice and Elderly Care Medicine, VU University Medical Center, Amsterdam, The Netherlands; Primary Care Research Centre, Institute of Population Health, University of Manchester, Manchester, UK.
Aartjan T F BeekmanAmsterdam Public Health Research Institute, Amsterdam, The Netherlands; Department of Psychiatry, VU University Medical Center / GGZ inGeest, Amsterdam, The Netherlands.
Marjolein VisserAmsterdam Public Health Research Institute, Amsterdam, The Netherlands; Department of Health Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands.
Brenda W J H PenninxAmsterdam Public Health Research Institute, Amsterdam, The Netherlands; Department of Psychiatry, VU University Medical Center / GGZ inGeest, Amsterdam, The Netherlands.
Natasja M van SchoorAmsterdam Public Health Research Institute, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands.
Amsterdam UMC Location VUmc · NLGGZ inGeest · NLVrije Universiteit Amsterdam · NLManchester Academic Health Science Centre · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDepressive symptoms and low vitamin D status are common in older persons and may be associated, but findings are inconsistent. This study investigated whether 25-hydroxyvitamin D (25(OH)D) concentrations are associated with depressive symptoms in older adults, both cross-sectionally and longitudinally. We also examined whether physical functioning could explain this relationship, to gain a better understanding of the underlying mechanisms.

methodsData from two independent prospective cohorts of the Longitudinal Aging Study Amsterdam were used: an older cohort (≥65 years, n = 1282, assessed from 1995-2002) and a younger-old cohort (55-65 years, n = 737, assessed from 2002-2009). MEASUREMENTS: Depressive symptoms were measured at baseline and after 3 and 6 years with the Center of Epidemiological Studies Depression Scale. Cross-sectional and longitudinal linear regression techniques were used to examine the relationship between 25(OH)D and depressive symptoms. The mediating role of physical functioning was examined in the longitudinal models.

resultsCross-sectionally, associations were not significant after adjustment for confounders. Longitudinally, women in the older cohort with baseline 25(OH)D concentrations up to 75 nmol/L experienced 175 to 24% more depressive symptoms in the following 6 years, compared with women with 25(OH)D concentrations >75 nmol/L. Reduced physical performance partially mediated this relationship. In men and in the younger-old cohort, no significant associations were observed.

conclusionsOlder women showed an inverse relationship between 25(OH)D and depressive symptoms over time, which may partially be explained by declining physical functioning. Replication of these findings by future studies is needed.

Indexed as

Physical Functional PerformanceAgedAged, 80 and overAge FactorsCross-Sectional StudiesDepressionFemaleHumansLongitudinal StudiesMaleMiddle AgedSex FactorsVitamin D25-hydroxyvitamin DVitamin Dcohort studydepressive symptomsolder personsphysical functioningVitamin D

Identifiers

PMID29628322
OpenAlexW2792044195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.