ArticleImmunity2018
The Immune Landscape of Cancer.
Erratum issued Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04941365 (Quantifying Systemic Immunosuppression to Personalize Cancer Therapy), which is not on this map. Cited by 3,812 papers.
0numbers the graph read from it
0cells of the map it votes in
3,812citing papers in PubMed
200.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Quantifying Systemic Immunosuppression to Personalize Cancer Therapy
Who cites it
3,812 citing papers in PubMed, 6,071 citations in OpenAlex.
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- Serial H&E Pathology Reveals Progression-Associated Nuclear Size Drift as a Longitudinal Digital Readout of Bladder Cancer Evolution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- High Expression of Aurora Kinase A (AURKA) is Associated with Aggressive Tumor Biology and Therapeutic Response in ER+/HER2- Breast Cancer.Annals of surgical oncology · 2026Article
- Tumor gasdermin E acts as a rheostat to limit apoptotic cell survival and mutagenesis in anticancer immune environments.Science advances · 2026Article
- Differences between mitotically old and young endometrial tumors.The Journal of pathology · 2026Article
- Comprehensive identification of FoxO signaling as a promising prognostic and immunotherapeutic biomarker in glioma.Journal of neuropathology and experimental neurology · 2026Article
- Pan-cancer epigenetic landscape of human tumor-associated macrophages reveals crucial enhancers governing their heterogenous formation by Pol II pausing modulation.Journal of advanced research · 2026Article
- Preclinical Characterization of CLSP-1025, a First-in-Class, Mutation-Specific T-Cell Engager Targeting a Neoantigen Derived from a Common p53 Mutation.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- Tumour-agnostic immunotherapy: aligning biological rationale, biomarker precision, and real-world implementation.EClinicalMedicine · 2026Review
- Cooccurrence of Homologous Recombination Deficiency and Mismatch Repair Deficiency in Colorectal Cancer.MedComm · 2026Article
- The Impact of SF3B1 Mutations on the Tumor Microenvironment and Response to Immunotherapy.Cancer medicine · 2026Article
- A meta-interaction basis for cell-cell communication in tissues.bioRxiv : the preprint server for biology · 2026Article
- Transformer-Based Multitask Framework Integrating Habitat and Deep Learning for Predicting Early Disease Control and Survival in Immunotherapy-Treated Hepatocellular Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The HBV basal core promoter mutation confers a replicative advantage and transcriptionally reprograms hepatocytes toward HCC subtypes.bioRxiv : the preprint server for biology · 2026Article
- Nuclear Medicine Tracers Targeting Tumor-Associated Macrophages.Pharmaceutics · 2026Review
- Clinical translation of senescence-related pan-cancer multi-omics: tools for assessment and immunotherapy prediction.Cancer gene therapy · 2026Article
- PhenoMapR: scalable mapping of sample phenotypes to single-cell, spatial, and bulk transcriptomics data.bioRxiv : the preprint server for biology · 2026Article
3,752 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
58 authors at 20 institutions in 6 countries.
Vésteinn ThorssonInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA. Electronic address: vesteinn.thorsson@systemsbiology.org.
David L GibbsInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA.
Scott D BrownCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
Denise WolfUniversity of California, San Francisco, Box 0808, 2340 Sutter Street, S433, San Francisco, CA 94115, USA.
Dante S BortoneLineberger Comprehensive Cancer Center, Curriculum in Bioinformatics and Computational Biology, University of North Carolina, 125 Mason Farm Road, Chapel Hill, NC 27599-7295, USA.
Tai-Hsien Ou YangDepartment of Systems Biology and Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.
Eduard Porta-PardoBarcelona Supercomputing Centre, c/Jordi Girona, 29, 08034 Barcelona, Spain; SBP Medical Discovery Institute, La Jolla, CA 92037, USA.
Galen F GaoThe Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Christopher L PlaisierInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA; School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85281, USA.
James A EddySage Bionetworks, 2901 Third Ave, Suite 330, Seattle, WA 98121, USA.
Elad ZivDepartment of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 1450 3rd St, San Francisco, CA 94143, USA.
Aedin C CulhaneDepartment of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Evan O PaullIrving Cancer Research Center, Room 913,1130 St. Nicholas Avenue, New York, NY 10032, USA.
I K Ashok SivakumarDepartment of Computer Science, Institute for Computational Medicine; Johns Hopkins University, Baltimore, MD 21218, USA.
Andrew J GentlesDepartments of Medicine and Biomedical Data Science, Stanford University, Stanford, CA 94305, USA.
Raunaq MalhotraSeven Bridges Genomics, Cambridge, MA 02142, USA.
Farshad FarshidfarDepartment of Oncology, University of Calgary, Calgary, AB T2N 4N1, Canada.
Antonio ColapricoUniversite libre de Bruxelles (ULB), Computer Science Department, Faculty of Sciences, Boulevard du Triomphe - CP212, 1050 Bruxelles, Belgium.
Joel S ParkerLineberger Comprehensive Cancer Center, Curriculum in Bioinformatics and Computational Biology, University of North Carolina, 125 Mason Farm Road, Chapel Hill, NC 27599-7295, USA.
Lisle E MoseLineberger Comprehensive Cancer Center, Curriculum in Bioinformatics and Computational Biology, University of North Carolina, 125 Mason Farm Road, Chapel Hill, NC 27599-7295, USA.
Nam Sy VoDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jianfang LiuChan Soon-Shiong Institute of Molecular Medicine at Windber, Windber, PA 15963, USA.
Yuexin LiuDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Janet RaderMedical College of Wisconsin, 9200 Wisconsin Avenue, Milwaukee, WI 53226 USA.
Varsha DhankaniInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA.
Sheila M ReynoldsInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA.
Reanne BowlbyCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
Andrea CalifanoIrving Cancer Research Center, Room 913,1130 St. Nicholas Avenue, New York, NY 10032, USA.
Andrew D CherniackThe Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Dimitris AnastassiouDepartment of Systems Biology and Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.
Davide BedognettiDivision of Translational Medicine, Research Branch, Sidra Medical and Research Center, PO Box 26999, Doha, Qatar.
Younes MokrabDivision of Translational Medicine, Research Branch, Sidra Medical and Research Center, PO Box 26999, Doha, Qatar.
Aaron M NewmanInstitute for Stem Cell Biology and Regenerative Medicine and Department of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA.
Arvind RaoDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Ken ChenDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Alexander KrasnitzSimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.
Hai HuChan Soon-Shiong Institute of Molecular Medicine at Windber, Windber, PA 15963, USA.
Tathiane M MaltaDepartment of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA; Department of Genetics, Ribeirao Preto Medical School, University of São Paulo, São Paulo, Brazil.
Houtan NoushmehrDepartment of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA; Department of Genetics, Ribeirao Preto Medical School, University of São Paulo, São Paulo, Brazil.
Chandra Sekhar PedamalluDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Susan BullmanDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Akinyemi I OjesinaUniversity of Alabama at Birmingham, Birmingham, AL 35294, USA.
Andrew LambSage Bionetworks, 2901 Third Ave, Suite 330, Seattle, WA 98121, USA.
Wanding ZhouCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
Hui ShenCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
Toni K ChoueiriDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
John N WeinsteinDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Justin GuinneySage Bionetworks, 2901 Third Ave, Suite 330, Seattle, WA 98121, USA.
Joel SaltzDepartment of Biomedical Informatics, Stony Brook Medicine, 100 Nicolls Rd, Stony Brook, NY 11794, USA.
Robert A HoltCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
Charles S RabkinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Dr., Bethesda, MD 20892, USA.
Cancer Genome Atlas Research Network
Alexander J LazarDepartments of Pathology, Genomics Medicine and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd-Unit 85, Houston, TX 77030, USA.
Jonathan S SerodyDepartment of Medicine and Microbiology and Lineberger Comprehensive Cancer Center, 125 Mason Farm Road, Chapel Hill, NC 27599-7295, USA.
Elizabeth G DemiccoMount Sinai Hospital, Department of Pathology and Laboratory Medicine, 600 University Ave., Toronto, ON M5G 1X5, Canada.
Mary L DisisUW Medicine Cancer Vaccine Institute, 850 Republican Street, Brotman Building, 2nd Floor, Room 221, Box 358050, University of Washington, Seattle, WA 98109-4714, USA.
Benjamin G VincentLineberger Comprehensive Cancer Center, Curriculum in Bioinformatics and Computational Biology, University of North Carolina, 125 Mason Farm Road, Chapel Hill, NC 27599-7295, USA. Electronic address: benjamin.vincent@unchealth.unc.edu.
Ilya ShmulevichInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA. Electronic address: ilya.shmulevich@systemsbiology.org.
The University of Texas MD Anderson Cancer Center · USInstitute for Systems Biology · USBC Cancer Agency · CAUniversity of North Carolina at Chapel Hill · USSage Bionetworks · USDana-Farber Cancer Institute · USCancer Research Center · USSidra Medical and Research Center · QAVan Andel Institute · USUNC Lineberger Comprehensive Cancer CenterBroad Institute · USColumbia University · USMount Sinai Hospital · CAWindber Research Institute · USUniversity of Washington · USStanford University · USUniversidade de São Paulo · BRUniversity of California, San Francisco · USNational Cancer Institute · USStony Brook Medicine · US
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MLarge Scale Genome SequencingU54HG003079 · NHGRI · WASHINGTON UNIVERSITY · PI DUTCHER, SUSAN K · 2004 to 2016
$445.7MThe Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3MTumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MVirology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5MSingle-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9MTissue Procurement & PathologyP50CA058223 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHARLES M PEROU · 1992 to 2026
$59.3MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MUsing Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Dingran Chang, Steven Allan Soper · 2019 to 2026
$21.5MGene Expression Patterns in Human Tumors Identified Using Transcript SequencingU24CA143848 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAYES, DAVID N, PEROU, CHARLES M · 2009 to 2016
$20.8MGenome Characterization Center (GCC)U24CA143867 · NCI · BROAD INSTITUTE, INC. · PI GABRIEL, STACEY, MEYERSON, MATTHEW L. · 2009 to 2016
$17.0MThe Cancer Genome Atlas Data Analysis CenterU24CA143845 · NCI · BROAD INSTITUTE, INC. · PI CHIN, LYNDA, GETZ, GAD A · 2009 to 2016
$16.0MNCI NIH HHS K24 CA169004NCI NIH HHS P30 CA016086NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA045508NCI NIH HHS P50 CA058223NCI NIH HHS R01 CA163722NCI NIH HHS R01 CA184585NCI NIH HHS R35 CA197745NCI NIH HHS R50 CA221675NCI NIH HHS U01 CA217858NCI NIH HHS U24 CA143799NCI NIH HHS U24 CA143835NCI NIH HHS U24 CA143840NCI NIH HHS U24 CA143843NCI NIH HHS U24 CA143845NCI NIH HHS U24 CA143848NCI NIH HHS U24 CA143858NCI NIH HHS U24 CA143866NCI NIH HHS U24 CA143867NCI NIH HHS U24 CA143882NCI NIH HHS U24 CA143883NCI NIH HHS U24 CA144025NCI NIH HHS U24 CA180924NCI NIH HHS U24 CA210949NCI NIH HHS U24 CA210950NCI NIH HHS U24 CA210957NCI NIH HHS U24 CA210969NCI NIH HHS U24 CA210990NCI NIH HHS U54 CA209997NHGRI NIH HHS U54 HG003067NHGRI NIH HHS U54 HG003079NHGRI NIH HHS U54 HG003273NIEHS NIH HHS P30 ES010126NIGMS NIH HHS P20 GM130423NIH HHS S10 OD012351NIH HHS S10 OD021764NLM NIH HHS R01 LM009239
Abstract
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β dominant-characterized by differences in macrophage or lymphocyte signatures, Th1:Th2 cell ratio, extent of intratumoral heterogeneity, aneuploidy, extent of neoantigen load, overall cell proliferation, expression of immunomodulatory genes, and prognosis. Specific driver mutations correlated with lower (CTNNB1, NRAS, or IDH1) or higher (BRAF, TP53, or CASP8) leukocyte levels across all cancers. Multiple control modalities of the intracellular and extracellular networks (transcription, microRNAs, copy number, and epigenetic processes) were involved in tumor-immune cell interactions, both across and within immune subtypes. Our immunogenomics pipeline to characterize these heterogeneous tumors and the resulting data are intended to serve as a resource for future targeted studies to further advance the field.
Indexed as
NeoplasmsAdolescentAdultAgedAged, 80 and overChildFemaleGenomicsHumansInterferon-gammaMacrophagesMaleMiddle AgedPrognosisTh1-Th2 BalanceTransforming Growth Factor betaIFNG protein, humanInterferon-gammaTransforming Growth Factor betacancer genomicsimmune subtypesimmunomodulatoryimmuno-oncologyimmunotherapyintegrative network analysistumor immunologytumor microenvironment
Identifiers
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Registered trials
NCT04941365ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.