ArticlePsychiatry research. Neuroimaging2018
Associations between adolescent cannabis use and brain structure in psychosis.
Article in Psychiatry research. Neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does Cannabis Use Contribute to Schizophrenia? A Causation Analysis Based on Epidemiological Evidence.Biomolecules · 2025Pooled it
- Disruption of Reelin signaling in a dual-hit mouse model of schizophrenia: impact of postnatal Δ9-tetrahydrocannabinol exposure in a maternal immune activation model.Translational psychiatry · 2026Article
- Investigating the polygenic relationship between heavy cannabis use and schizophrenia in the All of Us Research Program.Psychological medicine · 2025Article
- Chronic cannabis use in people with bipolar disorder is associated with comparable decision-making and functional outcome to healthy participants.Translational psychiatry · 2025Article
- Cannabis Use in Adolescents.Delaware journal of public health · 2025Article
- Exposotypes in psychotic disorders.Scientific reports · 2025Article
- Axis I Psychiatric Disorders and Substance Abuse: A Systematic Review of Neuroimaging Findings.Journal of clinical medicine · 2025Review
- Associations between cannabis use, cannabis use disorder, and mood disorders: longitudinal, genetic, and neurocognitive evidence.Psychopharmacology · 2022Review
- The relationship between cannabis use and cognition in people with bipolar disorder: A systematic scoping review.Psychiatry research · 2021Article
- Adolescent Substance Abuse, Transgenerational Consequences and Epigenetics.Current neuropharmacology · 2021Article
- The Association Between Cannabis Use and Schizophrenia: Causative or Curative? A Systematic Review.Cureus · 2020Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Associations between cannabis use and psychotic disorders suggest that cannabis may be a contributory risk factor in the neurobiology of psychosis. In this study, we examined brain structure characteristics, total and regional gray matter density (GMD), using Voxel Based Morphometry, in psychotic individuals, stratified by history of cannabis use (total n = 109). We also contrasted GMD estimates in individual diagnostic groups (schizophrenia/bipolar I disorder) with and without history of adolescent cannabis use (ACU). Individuals with psychosis as a whole, both with and without history of ACU, had lower total and regional GMD, compared to healthy controls. ACU was associated with attenuated GMD reductions, compared to non-users, especially in the schizophrenia cases, who showed robust GMD reductions in fronto-temporal and parietal cortex, as well as subcortical regions. Notably, total and regional GMD estimates in individuals with psychosis and ACU were not different from controls with no ACU. These data indicate that the history of ACU in psychotic individuals is associated with attenuated GMD abnormalities. Future investigations targeting potential unique etiological and risk factors associated with psychosis in individuals with ACU may help in understanding of the neurobiology of psychotic disorders and novel treatment options for these individuals.
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