ArticleNeuron2018
Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei.
Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers.
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Who cites it
145 citing papers in PubMed, 247 citations in OpenAlex.
- Intrinsic connections between thalamic sub-regions and the lateral prefrontal cortex are differentially impacted by acute methylphenidate.Psychopharmacology · 2020Trial
- Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility.Neuron · 2026Article
- Paratenial thalamus engages in reciprocal and broadcast circuits with the prefrontal cortex.Cell reports · 2026Article
- Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice.Neurobiology of disease · 2026Article
- A prefrontal peptidergic circuit for psychogenic itch.Science advances · 2026Article
- Region- and Layer-Specific Glutamatergic Synapse Development in the Nascent Cortical Hierarchy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Integration of cortical inputs in the lateral hypothalamus is dominated by the medial prefrontal cortex.The Journal of physiology · 2026Article
- Prefrontal gamma oscillations engage dynamic cell-type-specific configurations to support flexible behavior.Neuron · 2026Article
- Thalamic Subregion Alterations and Short-Chain Fatty Acids in Schizophrenia and Ultra-High-Risk Individuals: A Cross-Sectional Study.Alpha psychiatry · 2026Article
- Article
- Antidepressant-like effects of extinction learning as an animal model of behavioral therapy.Molecular psychiatry · 2026Article
- Disrupted Development of the mPFC-Thalamic Circuit in Shank3Molecular psychiatry · 2026Article
- The role of transthalamic pathways in perception.Communications biology · 2026Review
- Network-nodal tACS induces right-lateralization of thalamocortical connectivity.Scientific reports · 2026Article
- Distinct mediodorsal-prefrontal loops differentially encode reward-predictive cues.bioRxiv : the preprint server for biology · 2026Article
- Submedius thalamic inputs shape the presynaptic architecture of layer 5 orbitofrontal cortex in mice.iScience · 2026Article
- Article
- A molecularly defined basalo-prefrontal-thalamic circuit regulates sensory and affective dimensions of pain in male mice.Nature communications · 2026Article
- Prefrontal spine loss in neuropsychiatric disorders: circuit consequences for cognition.Frontiers in psychiatry · 2026Review
- Microglial VRK2 Regulates Astrocytic GABA Synthesis and Tonic Inhibition in the Thalamus.Glia · 2026Article
85 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Reciprocal interactions between the prefrontal cortex (PFC) and thalamus play a critical role in cognition, but the underlying circuits remain poorly understood. Here we use optogenetics to dissect the specificity and dynamics of cortico-thalamo-cortical networks in the mouse brain. We find that cortico-thalamic (CT) neurons in prelimbic PFC project to both mediodorsal (MD) and ventromedial (VM) thalamus, where layer 5 and 6 inputs activate thalamo-cortical (TC) neurons with distinct temporal profiles. We show that TC neurons in MD and VM in turn make distinct connections in PFC, with MD preferentially and strongly activating layer 2/3 cortico-cortical (CC) neurons. Finally, we assess local connections from superficial CC to deep CT neurons, which link thalamo-cortical and cortico-thalamic networks within the PFC. Together our findings indicate that PFC strongly drives neurons in the thalamus, whereas MD and VM indirectly influence reciprocally connected neurons in the PFC, providing a mechanistic understanding of these circuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.