ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2018
Modulating Emotion Perception: Opposing Effects of Inhibitory and Excitatory Prefrontal Cortex Stimulation.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Does non-invasive brain stimulation modulate emotional stress reactivity?Social cognitive and affective neuroscience · 2020Pooled it
- Effects of Repetitive Transcranial Magnetic Stimulation on Upper Limb Motor Function and Serum Lipid Metabolomics in Patients With Ischemic Stroke: A Randomized Controlled Study.Brain and behavior · 2025Trial
- Neural Oscillations Underlying Guilt-Related Modulation of Visual Size Perception.Behavioral sciences (Basel, Switzerland) · 2026Article
- Effect of database, pre-processing pipeline, and scan duration on rs-fMRI functional connectivity based treatment targets for TMS obtained using the Stanford Neuromodulation Therapy (SNT) protocol.Psychoradiology · 2026Article
- Effects of Continuous Theta Burst Stimulation to the Dorsolateral Prefrontal Cortex on Attention to Emotional Stimuli: A Randomized Controlled Trial.Brain sciences · 2025Article
- Prefrontal-Dependent and Gender-Specific Modulation of Guilt Emotion on Human Early Visual Perception.Behavioral sciences (Basel, Switzerland) · 2025Article
- Research advances in neuronavigated target localization for repetitive transcranial magnetic stimulation in depression: from standardization to individualized neuromodulation.Frontiers in neuroimaging · 2025Review
- Review
- Transcranial alternating current stimulation ameliorates emotional attention through neural oscillations modulation.Cognitive neurodynamics · 2023Article
- Review
- Trait-related neural basis of attentional bias to emotions: a tDCS study.Cognitive, affective & behavioral neuroscience · 2023Article
- Bioelectromagnetism in Human Brain Research: New Applications, New Questions.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023Review
- Non-invasive stimulation reveals ventromedial prefrontal cortex function in reward prediction and reward processing.Frontiers in neuroscience · 2023Article
- Noninvasive stimulation of the ventromedial prefrontal cortex modulates rationality of human decision-making.Scientific reports · 2022Article
- [Neurofeedback technology based on functional near infrared spectroscopy imaging and its applications].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2022Article
- Layer III pyramidal cells in the prefrontal cortex reveal morphological changes in subjects with depression, schizophrenia, and suicide.Translational psychiatry · 2022Article
- Neural correlates of negative emotion processing in subthreshold depression.Social cognitive and affective neuroscience · 2022Article
- rTMS Reduces Craving and Alcohol Use in Patients with Alcohol Use Disorder: Results of a Randomized, Sham-Controlled Clinical Trial.Journal of clinical medicine · 2022Article
- An engram of intentionally forgotten information.Nature communications · 2021Article
- Personalised, image-guided, noninvasive brain stimulation in gliomas: Rationale, challenges and opportunities.EBioMedicine · 2021Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExcitatory repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (dlPFC) is approved by the U.S. Food and Drug Administration for the treatment of adult patients with treatment-resistant major depressive disorder (MDD). This stimulation is supposed to restore excitability of prefrontal cortex regions that exhibit diminished regulation of emotion-generative systems in MDD. Based on the valence lateralization hypothesis, inhibitory rTMS of the right dlPFC has also been applied in MDD. This approach has proved to be effective, although meta-analyses of emotional perception and affective regulation in healthy control subjects and patients with depression do not support functional asymmetries within dlPFC regions.
methodsTo shed more light on this discrepancy, the effects of excitatory and inhibitory rTMS of the right dlPFC on visual emotional perception were compared in two groups of 41 healthy participants overall. Before and after rTMS stimulation, participants viewed fearful and neutral faces while whole-head magnetoencephalography was recorded and supplemented by behavioral tests.
resultsVisual sensory processing of fearful facial expressions, relative to neutral facial expressions, was reduced after excitatory stimulation and was increased after inhibitory stimulation within right occipital and right temporal regions. Correspondingly, after excitatory rTMS compared with inhibitory rTMS, participants displayed relatively reduced reaction times in an emotion discrimination task and showed reduced emotional arousal.
conclusionsThese results support the hypothesis that excitatory rTMS compared with inhibitory rTMS of the right dlPFC strengthens top-down control of aversive stimuli in healthy control subjects, which should encourage more research on mechanisms of excitatory/inhibitory dlPFC-rTMS protocols in general and on neuromodulatory treatment of MDD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.