Evidence map›Paper›PMID 29627965›Full record

ArticleMolecular biology reports2018

Association of T/A polymorphism in miR-1302 binding site in CGA gene with male infertility in Isfahan population.

Mina Jamalvandi, Majid Motovali-Bashi, Farzane Amirmahani, Parisa Darvishi, Kiarash Jamshidi Goharrizi

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Mina JamalvandiDepartment of Immunology, Faculty of Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran.
Majid Motovali-BashiGenetic Division, Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, 81746-73441, Iran. mbashi@sci.ui.ac.ir.ORCID http://orcid.org/0000-0003-4380-0166
Farzane AmirmahaniGenetic Division, Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, 81746-73441, Iran.
Parisa DarvishiDepartment of Immunology, Faculty of Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran.
Kiarash Jamshidi GoharriziDepartment of Plant Breeding, Yazd Branch, Islamic Azad University, Yazd, Iran.
Medical University of Ilam · IRIsfahan University of Medical Sciences · IRIslamic Azad University, Yazd · IRUniversity of Isfahan · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infertility occurs in 10-15% of couples worldwide and close to half of it is caused by male factors. One of the genes that can affect male infertility is CGA. Polymorphisms in CGA gene may affect gene expression, therefore affecting male infertility by disrupting the regulation of this gene. One of the polymorphisms is the substitution of T with A in the miR-1302 binding site in the 3' untranslated region of the CGA gene. In this study, we explored this polymorphism in Isfahan population. In this case-control study, by the use of Tetra primer-ARMS-PCR technique, rs6631 has been investigated in 224 infertile men and 196 controls. Infertile men were recruited from Isfahan Fertility and Infertility Center. Analysis of genotype and allele frequencies indicated that the differences between case and control populations were significant for rs6631 because P = 0.00 which is above the threshold. We found a significant relationship between this polymorphism and male infertility. This study which performed for the first time in Iran suggests that polymorphism in CGA gene can affect male infertility. Also, this polymorphism has high heterozygosity, so it can be used for further studies in different populations.

Indexed as

3' Untranslated RegionsAdultCase-Control StudiesGene FrequencyGenetic Predisposition to DiseaseGenotypeGlycoprotein Hormones, alpha SubunitHumansInfertility, MaleIranMaleMicroRNAsPolymorphism, Single NucleotideRNA-Binding Motifs3' Untranslated RegionsCGA protein, humanGlycoprotein Hormones, alpha SubunitMicroRNAsCGA geneGlycoprotein hormonesMale infertilityPolymorphism

Identifiers

PMID29627965
OpenAlexW2795844618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.