Trial reportSocial psychiatry and psychiatric epidemiology2018
Cross-sectional networks of depressive symptoms before and after antidepressant medication treatment.
Trial report in Social psychiatry and psychiatric epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review and Individual Patient Data Network Analysis of the Residual Symptom Structure Following Cognitive-Behavioral Therapy and Escitalopram, Mirtazapine and Venlafaxine for Depression.Frontiers in psychiatry · 2022Pooled it
- A network approach exploring the effects of cognitive remediation on cognition, symptoms, and functioning in early psychosis.Psychological medicine · 2025Trial
- Implications of the Network Theory for the Treatment of Mental Disorders: A Secondary Analysis of a Randomized Clinical Trial.JAMA psychiatry · 2023Trial
- The complex clinical response to selective serotonin reuptake inhibitors in depression: a network perspective.Translational psychiatry · 2023Trial
- Network dynamics of depressive symptoms in antidepressant medication treatment: secondary analysis of eight clinical trials.Molecular psychiatry · 2021Trial
- A network analysis of how obsessive-compulsive symptoms change during exposure and response prevention treatment.Psychological medicine · 2025Article
- Anticipating depression trajectories by measuring plasticity and change through symptom network dynamics.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- A network analysis of voice hearing, emotional distress and subjective recovery before and after cognitive behavioural interventions.European archives of psychiatry and clinical neuroscience · 2025Article
- Electroconvulsive therapy modulates the interplay between depressive symptoms in difficult-to-treat depression: A longitudinal network analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Symptom networks in major depressive disorder and treatment response: special focus on TRD.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Understanding the impact of COVID-19 on comorbid depression, anxiety and eating disorders in adolescent psychiatric inpatients: a network analysis.Child and adolescent psychiatry and mental health · 2025Article
- Network temperature as a metric of stability in depression symptoms across adolescence.Nature. Mental health · 2025Article
- The effect of sertraline on networks of mood and anxiety symptoms: secondary analysis of the PANDA randomized controlled trial.Nature. Mental health · 2025Article
- Characterizing the dynamics, reactivity and controllability of moods in depression with a Kalman filter.PLoS computational biology · 2024Article
- Proxy Responses in Research on COVID-19 Among People With Intellectual and Developmental Disabilities.American journal on intellectual and developmental disabilities · 2024Article
- A network analysis of exhaustion disorder symptoms throughout treatment.BMC psychiatry · 2024Article
- Centrality measures in psychological networks: A simulation study on identifying effective treatment targets.PloS one · 2024Article
- Network modeling of problematic social media use components in college student social media users.Frontiers in psychiatry · 2024Article
- Pathological network changes in patients with social anxiety disorder before and after an Internet-based CBT.Internet interventions · 2023Article
- Elevated emotion network connectivity is associated with fluctuations in depression.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
purposeRecent reviews have questioned the efficacy of selective serotonin reuptake inhibitors (SSRIs) above placebo response, and their working mechanisms remain unclear. New approaches to understanding the effects of SSRIs are necessary to enhance their efficacy. The aim of this study was to explore the possibilities of using cross-sectional network analysis to increase our understanding of symptom connectivity before and after SSRI treatment.
methodsIn two randomized controlled trials (total N = 178), we estimated Gaussian graphical models among 20 symptoms of the Beck Depression Inventory-II before and after 8 weeks of treatment with the SSRI paroxetine. Networks were compared on connectivity, community structure, predictability (proportion explained variance), and strength centrality (i.e., connectedness to other symptoms in the network).
resultsSymptom severity for all individual BDI-II symptoms significantly decreased over 8 weeks of SSRI treatment, whereas interconnectivity and predictability of the symptoms significantly increased. At baseline, three communities were detected; five communities were detected at week 8.
conclusionsFindings suggest the effects of SSRIs can be studied using the network approach. The increased connectivity, predictability, and communities at week 8 may be explained by the decrease in depressive symptoms rather than specific effects of SSRIs. Future studies with larger samples and placebo controls are needed to offer insight into the effects of SSRIs.
trial registrationThe trials described in this manuscript were funded by the NIMH. Pennsylvania/Vanderbilt study: 5 R10 MH55877 ( https://projectreporter.nih.gov/project_info_description.cfm?aid=6186633&icde=28344168&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC&MMOpt= ). Washington study: R01 MH55502 ( https://projectreporter.nih.gov/project_info_description.cfm?aid=2034618&icde=28344217&ddparam=&ddvalue=&ddsub=&cr=5&csb=default&cs=ASC ).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.