Evidence map›Paper›PMID 29627740›Full record

ArticleAtherosclerosis2018

Fatigability and functional performance among older adults with low-normal ankle-brachial index: Cross-sectional findings from the Baltimore Longitudinal Study of Aging.

Pablo Martinez-Amezcua, Kunihiro Matsushita, Eleanor M Simonsick, Luigi Ferrucci, Jennifer A Schrack

Open access · greenAbstract read
In one paragraph

Article in Atherosclerosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Fatigability: A Prognostic Indicator of Phenotypic Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Article
  6. Longitudinal Association Between Energy Regulation and Fatigability in Mid-to-Late Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Pablo Martinez-AmezcuaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Center on Aging and Health, Johns Hopkins University, Baltimore, MD, USA. Electronic address: pablov489@jhu.edu.
Kunihiro MatsushitaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Eleanor M SimonsickIntramural Research Program, National Institute on Aging, Baltimore, MD, USA.
Luigi FerrucciIntramural Research Program, National Institute on Aging, Baltimore, MD, USA.
Jennifer A SchrackDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Center on Aging and Health, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USNational Institute on Aging · US

Funding

The Baltimore Longitudinal Study Of AgingZIAAG000015 · NIA · NATIONAL INSTITUTE ON AGING · PI SIMONSICK, ELEANOR MARIE · 2009 to 2025
$116.9M
Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2M
THE BALTIMORE LONGITUDINAL STUDY OF HUMAN AGINGZ01AG000015 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 1985 to 2008
$11.4M
Defining and Quantifying Fatigability in Functionally Independent Older AdultsR21AG053198 · NIA · JOHNS HOPKINS UNIVERSITY · PI SCHRACK, JENNIFER ANN · 2016 to 2017
$449k
Intramural NIH HHS Z01 AG000015Intramural NIH HHS Z99 AG999999NIA NIH HHS P30 AG021334NIA NIH HHS R21 AG053198
6 · The paper itself

Abstract

BACKGROUND AND

aimsPeripheral artery disease (PAD) is associated with poor mobility and fatigue, but the relationship between preclinical ankle-brachial index (ABI) and early markers of fatigue and functional decline has not been defined.

methods570 adults, 50 and older, from the Baltimore Longitudinal Study of Aging (N = 570), with normal values of ABI (1-1.39), were classified into ABI tertiles. Perceived fatigability was assessed after a 5-min, treadmill walk (1.5 mph) using the Borg rating of perceived exertion (RPE, range 6-20). Functional evaluation included the Health, Aging and Body Composition Physical Performance Battery (HABC PPB), time to complete a 400-m corridor walk (LDCW), and VO

resultsMean LDCW time and RPE were greater for participants in the lowest tertile compared to those in the highest; mean VO

conclusionsLower ABI is associated with poorer physical function and increased fatigability, suggesting that early changes in ABI may infer greater risk of functional decline, even among those who may not progress to PAD.

Indexed as

AgingAnkle Brachial IndexFatiguePhysical Functional PerformanceAgedAged, 80 and overBaltimoreBody CompositionCardiorespiratory FitnessCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedMobility LimitationFatigabilityFunctional performancePeripheral artery disease

Identifiers

PMID29627740
PMCPMC5994755
OpenAlexW2792245324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.