ArticleJournal of the mechanical behavior of biomedical materials2018
Improving tissue expansion protocols through computational modeling.
Article in Journal of the mechanical behavior of biomedical materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Cell-Free Fat Extract (CEFFE) as a Versatile Cell-Free Biologic for Multitissue Regeneration: From Skin and Bone to Nerve, Reproductive, and Systemic Applications-A Comprehensive Review.BioMed research international · 2026Review
- Predictive Modeling of Human Skin Deformation and Growth During Tissue Expansion in Postmastectomy Breast Reconstruction.Journal of biomechanical engineering · 2025Article
- Development and calibration of digital twins for human skin growth in tissue expansion.Acta biomaterialia · 2025Article
- Tissue expansion mitigates radiation-induced skin fibrosis in a porcine model.Acta biomaterialia · 2024Article
- Numerical investigation of new rete ridge formation in a multi-layer model of skin subjected to tissue expansion.Journal of biomechanics · 2024Article
- Multi-Fidelity Gaussian Process Surrogate Modeling of Pediatric Tissue Expansion.Journal of biomechanical engineering · 2022Article
- Scalp reconstruction by tissue expansion: tips and tricks.Acta bio-medica : Atenei Parmensis · 2022Article
- PDE-constrained shape registration to characterize biological growth and morphogenesis from imaging data.Engineering with computers · 2022Article
- Langerhans cells and SFRP2/Wnt/beta-catenin signalling control adaptation of skin epidermis to mechanical stretching.Journal of cellular and molecular medicine · 2022Article
- Single-Cell Transcriptomics Uncover Key Regulators of Skin Regeneration in Human Long-Term Mechanical Stretch-Mediated Expansion Therapy.Frontiers in cell and developmental biology · 2022Article
- Bayesian calibration of a computational model of tissue expansion based on a porcine animal model.Acta biomaterialia · 2022Article
- Personalized Computational Models of Tissue-Rearrangement in the Scalp Predict the Mechanical Stress Signature of Rotation Flaps.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2021Article
- The Geometry of Incompatibility in Growing Soft Tissues: Theory and Numerical Characterization.Journal of the mechanics and physics of solids · 2021Article
- Non-InvasiveFrontiers in bioengineering and biotechnology · 2021Article
- Multifactorial analysis of the surgical outcomes of giant congenital melanocytic nevi: Single versus serial tissue expansion.Archives of plastic surgery · 2020Article
- Inflammatory Responses in Oro-Maxillofacial Region Expanded Using Anisotropic Hydrogel Tissue Expander.Materials (Basel, Switzerland) · 2020Article
- Transcriptomic analysis reveals dynamic molecular changes in skin induced by mechanical forces secondary to tissue expansion.Scientific reports · 2020Article
- Cell-free fat extract promotes tissue regeneration in a tissue expansion model.Stem cell research & therapy · 2020Article
- Propagation of uncertainty in the mechanical and biological response of growing tissues using multi-fidelity Gaussian process regression.Computer methods in applied mechanics and engineering · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Tissue expansion is a common technique in reconstructive surgery used to grow skin in vivo for correction of large defects. Despite its popularity, there is a lack of quantitative understanding of how stretch leads to growth of new skin. This has resulted in several arbitrary expansion protocols that rely on the surgeon's personal training and experience rather than on accurate predictive models. For example, choosing between slow or rapid expansion, or small or large inflation volumes remains controversial. Here we explore four tissue expansion protocols by systematically varying the inflation volume and the protocol duration in a porcine model. The quantitative analysis combines three-dimensional photography, isogeometric kinematics, and finite growth theory. Strikingly, all four protocols generate similar peak stretches, but different growth patterns: Smaller filling volumes of 30 ml per inflation did not result in notable expander-induced growth neither for the short nor for the long protocol; larger filling volumes of 60 ml per inflation trigger skin adaptation, with larger expander-induced growth in regions of larger stretch, and more expander-induced growth for the 14-day compared to the 10-day expansion protocol. Our results suggest that expander-induced growth is not triggered by the local stretch alone. While stretch is clearly a driver for growth, the local stretch at a given point is not enough to predict the expander-induced growth at that location. From a clinical perspective, our study suggests that longer expansion protocols are needed to ensure sufficient growth of sizable skin patches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.