Evidence map›Paper›PMID 29627574›Full record

ArticleBiochemical and biophysical research communications2018

Exosomes secreted by placental stem cells selectively inhibit growth of aggressive prostate cancer cells.

Taylor C Peak, Prakash P Praharaj, Gati K Panigrahi, Michael Doyle, Yixin Su, Isabel R Schlaepfer, Ravi Singh, Donald J Vander Griend, Julie Alickson, Ashok Hemal and 2 more

Abstract read
In one paragraph

Article in Biochemical and biophysical research communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Human placental-derived stem cell therapy ameliorates experimental necrotizing enterocolitis.American journal of physiology. Gastrointestinal and liver physiology · 2021
    Article
  9. Isolation and analysis methods of extracellular vesicles (EVs).Extracellular vesicles and circulating nucleic acids · 2021
    Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Exosomes for Diagnosis and Therapy in Gastrointestinal Cancers.International journal of molecular sciences · 2020
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Taylor C PeakDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Prakash P PraharajDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Gati K PanigrahiDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Michael DoyleDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Yixin SuDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Isabel R SchlaepferDivision of Medical Oncology, Genitourinary Cancer Program, University of Colorado School of Medicine, Aurora, CO, United States.
Ravi SinghDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Donald J Vander GriendDepartment of Surgery, Section of Urology, The University of Chicago, Chicago, IL, United States.
Julie AlicksonWake Forest Institute for Regenerative Medicine, United States.
Ashok HemalWake Forest Institute for Regenerative Medicine, United States; Department of Urology, Wake Forest School of Medicine, United States; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, United States.
Anthony AtalaWake Forest Institute for Regenerative Medicine, United States; Department of Urology, Wake Forest School of Medicine, United States.
Gagan DeepDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, United States; Department of Urology, Wake Forest School of Medicine, United States; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, United States. Electronic address: gdeep@wakehealth.edu.
Wake Forest University · USForest Institute · USAtrium Health Wake Forest Baptist · USUniversity of Chicago · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Development of a novel therapeutic agent that exploits specific vulnerabilities in claudin low breast cancerR01CA207222 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SINGH, RAVI N · 2017 to 2021
$1.7M
Targeting Lipid Oxidation for Prostate Cancer Imaging and TherapyK01CA168934 · NCI · UNIVERSITY OF COLORADO DENVER · PI SCHLAEPFER, ISABEL RUBIO · 2012 to 2016
$615k
Exosomes Promote Disease Aggressiveness in African American Prostate CancerR21CA199628 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DEEP, GAGAN · 2015 to 2016
$571k
NCI NIH HHS K01 CA168934NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA207222NCI NIH HHS R21 CA199628
6 · The paper itself

Abstract

The current paradigm in the development of new cancer therapies is the ability to target tumor cells while avoiding harm to noncancerous cells. Furthermore, there is a need to develop novel therapeutic options against drug-resistant cancer cells. Herein, we characterized the placental-derived stem cell (PLSC) exosomes (PLSC

Indexed as

CarcinogenesisCell Line, TumorCell ProliferationCell SurvivalExosomesFemaleHumansLipidsMaleNeoplasm InvasivenessPlacentaPregnancyProstatic NeoplasmsSignal TransductionStem CellsLipidsExosomesMass spectrometryPlacental stem cellsProstate cancerRetinoic acid receptor

Identifiers

PMID29627574
PMCPMC5929996
OpenAlexW2796576132

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.