Evidence map›Paper›PMID 29627188›Full record

Trial reportThe Journal of pediatrics2018

Maternal Black Race and Persistent Wheezing Illness in Former Extremely Low Gestational Age Newborns: Secondary Analysis of a Randomized Trial.

Katherine C Wai, Anna M Hibbs, Martina A Steurer, Dennis M Black, Jeanette M Asselin, Eric C Eichenwald, Philip L Ballard, Roberta A Ballard, Roberta L Keller, Trial of Late Surfactant (TOLSURF) Study Group

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01022580 (Trial of Late Surfactant for Prevention of Bronchopulmonary Dysplasia), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01022580 phase3completednot on this map

Trial of Late Surfactant for Prevention of Bronchopulmonary Dysplasia: A Study in Ventilated Preterm Infants Receiving Inhaled Nitric Oxide

TypeinterventionalSponsorRoberta BallardRan2010 to 2016Enrolled511ConditionsBronchopulmonary DysplasiaArmsInfasurf surfactant (ONY, Inc.), Sham (No Treatment)
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Randomised trial of azithromycin to eradicateArchives of disease in childhood. Fetal and neonatal edition · 2020
    Trial
  2. Review
  3. Early Origins of Chronic Obstructive Pulmonary Disease: Prenatal and Early Life Risk Factors.International journal of environmental research and public health · 2023
    Review
  4. Article
  5. Article
  6. Influences of environmental exposures on preterm lung disease.Expert review of respiratory medicine · 2021
    Review
  7. Observational
  8. Article
  9. Observational
  10. Bronchopulmonary dysplasia: what are its links to COPD?Therapeutic advances in respiratory disease
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Katherine C WaiDepartment of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, CA.
Anna M HibbsDepartment of Pediatrics, Rainbow Babies and Children's Hospital, Cleveland, OH.
Martina A SteurerDepartment of Pediatrics, UCSF Benioff Children's Hospital, San Francisco, CA; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA.
Dennis M BlackDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA.
Jeanette M AsselinDepartment of Pediatrics, UCSF Benioff Children's Hospital, Oakland, CA.
Eric C EichenwaldDepartment of Pediatrics, The University of Pennsylvania, Philadelphia, PA.
Philip L BallardDepartment of Pediatrics, UCSF Benioff Children's Hospital, San Francisco, CA.
Roberta A BallardDepartment of Pediatrics, UCSF Benioff Children's Hospital, San Francisco, CA.
Roberta L KellerDepartment of Pediatrics, UCSF Benioff Children's Hospital, San Francisco, CA. Electronic address: kellerr@ucsf.edu.
Trial of Late Surfactant (TOLSURF) Study Group
UCSF Benioff Children's Hospital · USUniversity of California, San Francisco · USUniversity of Pennsylvania · USRainbow Babies & Children's Hospital · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Trial of Late SURFactant (TOLSURF) to Prevent BPD - Clinical Coord CtrU01HL094338 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BALLARD, ROBERTA ANDERSON · 2009 to 2013
$7.4M
Trial Of Late SURFactant (TOLSURF) to Prevent BPD-Data Coordinating CenterU01HL094355 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BLACK, DENNIS M · 2009 to 2013
$1.2M
NCATS NIH HHS UL1 TR000004NHLBI NIH HHS U01 HL094338NHLBI NIH HHS U01 HL094355
6 · The paper itself

Abstract

objectiveTo evaluate the relationship between maternal self-reported race/ethnicity and persistent wheezing illness in former high-risk, extremely low gestational age newborns, and to quantify the contribution of socioeconomic, environmental, and biological factors on this relationship. STUDY

designWe assessed persistent wheezing illness determined at 18-24 months corrected (for prematurity) age in survivors of a randomized trial. Parents/caregivers were surveyed for wheeze and inhaled asthma medication use quarterly to 12 months, and at 18 and 24 months. We used multivariable analysis to evaluate the relationship of maternal race to persistent wheezing illness, and identified mediators for this relationship via formal mediation analysis.

resultsOf 420 infants (25.2 ± 1.2 weeks of gestation and 714 ± 166 g at birth, 57% male, 34% maternal black race), 189 (45%) had persistent wheezing illness. After adjustment for gestational age, birth weight, and sex, infants of black mothers had increased odds of persistent wheeze compared with infants of nonblack mothers (OR = 2.9, 95% CI 1.9, 4.5). Only bronchopulmonary dysplasia, breast milk diet, and public insurance status were identified as mediators. In this model, the direct effect of race accounted for 69% of the relationship between maternal race and persistent wheeze, whereas breast milk diet, public insurance status, and bronchopulmonary dysplasia accounted for 8%, 12%, and 10%, respectively.

conclusionsAmong former high-risk extremely low gestational age newborns, infants of black mothers have increased odds of developing persistent wheeze. A substantial proportion of this effect is directly accounted for by race, which may reflect unmeasured environmental influences, and acquired and innate biological differences.

trial registrationClinicalTrials.gov: NCT01022580.

Indexed as

Black or African AmericanMothersChild, PreschoolFemaleHumansInfantInfant, Extremely PrematureInfant, NewbornInfant, Premature, DiseasesMaleRespiration, ArtificialRespiratory SoundsRisk Factorsasthmaprematuritysocioeconomic factors

Identifiers

PMID29627188
PMCPMC6019148
OpenAlexW2801255458

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.