Evidence map›Paper›PMID 29627138›Full record

ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2018

Longitudinal Changes in Right Ventricular Function in Tetralogy of Fallot in the Initial Years after Surgical Repair.

Michael P DiLorenzo, Okan U Elci, Yan Wang, Anirban Banerjee, Tomoyuki Sato, Bonnie Ky, Elizabeth Goldmuntz, Laura Mercer-Rosa

Abstract readComparative Study
In one paragraph

Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Right Ventricular Strain in Patients With Ductal-Dependent Tetralogy of Fallot.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2023
    Article
  8. Right atrial function early after tetralogy of Fallot repair.The international journal of cardiovascular imaging · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Tetralogy of Fallot: cardiac imaging evaluation.Annals of translational medicine · 2020
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael P DiLorenzoDivision of Pediatric Cardiology, Department of Pediatrics, New York-Presbyterian/Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, New York. Electronic address: mpd2001@cumc.columbia.edu.
Okan U ElciBiostatistics and Data Management Core, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Yan WangDivision of Pediatric Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Anirban BanerjeeDivision of Pediatric Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Tomoyuki SatoDivision of Pediatric Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Bonnie KyPenn Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, Philadelphia, Pennsylvania; Department of Biostatistics and Epidemiology, The University of Pennsylvania, Philadelphia, Pennsylvania.
Elizabeth GoldmuntzDivision of Pediatric Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Laura Mercer-RosaDivision of Pediatric Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Funding

Training in Molecular Therapeutics for Pediatric CardiologyT32HL007915 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Robert J Levy, JOSEPH W ROSSANO · 1999 to 2026
$13.4M
Outcome and Right Ventricular Remodeling After Repair of Tetralogy of FallotK01HL125521 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI MERCER-ROSA, LAURA M. · 2015 to 2019
$791k
NHLBI NIH HHS K01 HL125521NHLBI NIH HHS T32 HL007915
6 · The paper itself

Abstract

backgroundRight ventricular (RV) dysfunction is associated with adverse long-term outcomes in patients with tetralogy of Fallot. Little is known about RV function in the first years after surgical repair. The aim of this study was to investigate perioperative changes in myocardial deformation using global longitudinal strain.

methodsA retrospective analysis of patients with surgically repaired tetralogy of Fallot was performed. Global longitudinal peak systolic RV strain was measured on early postoperative echocardiograms, two subsequent postoperative echocardiograms through 2 years postoperatively, and preoperative echocardiograms, when available. Preoperative and late follow-up strain was compared with strain in 0- to 8-month-old and 1- to 4-year-old control subjects, respectively.

resultsForty-seven patients were included. Compared with postoperative strain (7 ± 7 days postoperatively), strain at follow-up 1 (8.3 ± 4 months postoperatively) was significantly improved (-12.3 ± 3.3% vs -18.8 ± 2.5%, P < .001), with no additional improvement 23.2 ± 6 months postoperatively (-18.8 ± 2.5% vs -19.8 ± 3.1%, P = .12). Postoperative strain was worse than preoperative strain (n = 25, -12.5 ± 3.6% vs -18.4 ± 2.9%, P < .001). Compared with control subjects, preoperative strain was similar (-19.3 ± 3.8% vs -18.4 ± 2.9%, P = .30), though late follow-up strain was significantly worse (-27.7 ± 2.8% vs -19.8 ± 3.1%, P < .001).

conclusionsRV global longitudinal strain worsens in the early postoperative period following surgical repair of tetralogy of Fallot but recovers through 2 postoperative years. Despite recovery to preoperative values, the presence of RV dysfunction compared with control subjects suggests that long-term dysfunction may begin early. The trajectory of RV dysfunction through the later years needs further study.

Indexed as

Age FactorsCardiac Surgical ProceduresCase-Control StudiesChild, PreschoolEchocardiography, DopplerFemaleHumansInfantInfant, NewbornMaleMonitoring, PhysiologicPreoperative CarePrognosisRetrospective StudiesTetralogy of FallotTime FactorsCongenital heart diseasePerioperativeRight ventricleStrainTetralogy of Fallot

Identifiers

PMID29627138
PMCPMC6035101

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.