Evidence map›Paper›PMID 29626765›Full record

ArticleDNA repair2018

Oxidatively-induced DNA damage and base excision repair in euthymic patients with bipolar disorder.

Deniz Ceylan, Gamze Tuna, Güldal Kirkali, Zeliha Tunca, Güneş Can, Hidayet Ece Arat, Melis Kant, Miral Dizdaroglu, Ayşegül Özerdem

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in DNA repair, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Deniz CeylanVocational School of Health Services, Izmir University of Economics, Izmir, Turkey; Department of Neuroscience, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey. Electronic address: denizceylandr@gmail.com.
Gamze TunaDepartment of Molecular Medicine, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey.
Güldal KirkaliThoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Bethesda, MD, 20892, USA.
Zeliha TuncaDepartment of Psychiatry, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
Güneş CanDepartment of Psychiatry, Mardin State Hospital, Mardin, Turkey.
Hidayet Ece AratDepartment of Psychology, Istanbul Gelişim University, Istanbul, Turkey, Turkey.
Melis KantDepartment of Medical Biochemistry, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey.
Miral DizdarogluBiomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD, 20899, USA. Electronic address: miral.dizdar@nist.gov.
Ayşegül ÖzerdemDepartment of Neuroscience, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey; Department of Psychiatry, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
Dokuz Eylül University · TRGelişim Üniversitesi · TRİzmir University of Economics · TRMardin Artuklu University · TRNational Cancer Institute · USNational Institute of Standards and Technology · US

Funding

Intramural NIST DOC 9999-NIST
6 · The paper itself

Abstract

Oxidatively-induced DNA damage has previously been associated with bipolar disorder. More recently, impairments in DNA repair mechanisms have also been reported. We aimed to investigate oxidatively-induced DNA lesions and expression of DNA glycosylases involved in base excision repair in euthymic patients with bipolar disorder compared to healthy individuals. DNA base lesions including both base and nucleoside modifications were measured using gas chromatography-tandem mass spectrometry and liquid chromatography-tandem mass spectrometry with isotope-dilution in DNA samples isolated from leukocytes of euthymic patients with bipolar disorder (n = 32) and healthy individuals (n = 51). The expression of DNA repair enzymes OGG1 and NEIL1 were measured using quantitative real-time polymerase chain reaction. The levels of malondialdehyde were measured using high performance liquid chromatography. Seven DNA base lesions in DNA of leukocytes of patients and healthy individuals were identified and quantified. Three of them had significantly elevated levels in bipolar patients when compared to healthy individuals. No elevation of lipid peroxidation marker malondialdehyde was observed. The level of OGG1 expression was significantly reduced in bipolar patients compared to healthy individuals, whereas the two groups exhibited similar levels of NEIL1 expression. Our results suggest that oxidatively-induced DNA damage occurs and base excision repair capacity may be decreased in bipolar patients when compared to healthy individuals. Measurement of oxidatively-induced DNA base lesions and the expression of DNA repair enzymes may be of great importance for large scale basic research and clinical studies of bipolar disorder.

Indexed as

DNA DamageDNA RepairOxidative StressAdultBipolar DisorderChromatography, LiquidDNADNA GlycosylasesFemaleGene Expression RegulationHumansMaleMiddle AgedTandem Mass SpectrometryDNADNA GlycosylasesNEIL1 protein, humanoxoguanine glycosylase 1, humanBase excision repairBipolar disorderDNA damageDNA repairFormamidopyrimidines

Identifiers

PMID29626765
PMCPMC7243967
OpenAlexW2794704746

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.