Evidence map›Paper›PMID 29626666›Full record

ArticleMolecular phylogenetics and evolution2018

Filtering nucleotide sites by phylogenetic signal to noise ratio increases confidence in the Neoaves phylogeny generated from ultraconserved elements.

Princess S Gilbert, Jing Wu, Margaret W Simon, Janet S Sinsheimer, Michael E Alfaro

Abstract read
In one paragraph

Article in Molecular phylogenetics and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
6.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. A region of suppressed recombination misleads neoavian phylogenomics.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Princess S GilbertDepartment of Ecology & Evolutionary Biology, University of California, Los Angeles, CA, USA. Electronic address: ps.gilbert@ucla.edu.
Jing WuHenry Samueli School of Engineering and Applied Science, Department of Computer Science, University of California, Los Angeles, CA, USA.
Margaret W SimonDepartment of Ecology & Evolutionary Biology, University of California, Los Angeles, CA, USA.
Janet S SinsheimerDepartment of Biomathematics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA, USA.
Michael E AlfaroDepartment of Ecology & Evolutionary Biology, University of California, Los Angeles, CA, USA. Electronic address: michaelalfaro@ucla.edu.
University of California, Los Angeles · USSamueli Institute · US

Funding

STATISTICAL METHODS FOR GENE MAPPINGR01GM053275 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LANGE, KENNETH L · 1995 to 2019
$9.3M
Training Grant in Genomic Analysis and InterpretationT32HG002536 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Valerie A Arboleda, Harold Pimentel · 2002 to 2026
$8.6M
Bayesian Joint Estimation of Alignment and PhylogenyR01GM086887 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUCHARD, MARC A. · 2008 to 2012
$1.5M
NHGRI NIH HHS T32 HG002536NIGMS NIH HHS R01 GM053275NIGMS NIH HHS R01 GM086887
6 · The paper itself

Abstract

Despite genome scale analyses, high-level relationships among Neoaves birds remain contentious. The placements of the Neoaves superorders are notoriously difficult to resolve because they involve deep splits followed by short internodes. Using our approach, we investigate whether filtering UCE loci on their phylogenetic signal to noise ratio helps to resolve key nodes in the Neoaves tree of life. We find that our analysis of data sets filtered for high signal to noise ratio results in topologies that are inconsistent with unfiltered results but that are congruent with whole-genome analyses. These relationships include the Columbea + Passerea sister relationship and the Phaethontimorphae + Aequornithia sister relationship. We also find increased statistical support for more recent nodes (i.e. the Pelecanidae + Ardeidae sister relationship, the Eucavitaves clade, and the Otidiformes + Musophagiformes sister relationship). We also find instances where support is reduced for well-established clades, possibly due to the removal of sites with moderate signal-to-noise ratio. Our results suggest that filtering on the basis of signal to noise ratio is a useful tool for resolving problematic splits in phylogenomic data sets.

Indexed as

PhylogenySignal-To-Noise RatioAnimalsBirdsNucleotidesRegulatory Sequences, Nucleic AcidNucleotidesNeoavesNon-coding DNAPhylogenetic signalUltraconserved elements

Identifiers

PMID29626666
PMCPMC6217972
OpenAlexW2795931597

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.