ReviewHormones and behavior2018
Diverse actions of estradiol on anorexigenic and orexigenic hypothalamic arcuate neurons.
Review in Hormones and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 51 citations in OpenAlex.
- Sexual dimorphism in the development and function of the melanocortin system.Reviews in endocrine & metabolic disorders · 2026Review
- Estrous cycle modulates fasting-induced torpor propensity via hypothalamic estrogen signalling.Scientific reports · 2026Article
- Functional Integration of Different-Sex Gonad Transplants Into the Adult Mouse Hypothalamic Pituitary Gonadal Axis.Advanced biology · 2026Article
- The role of ovarian hormone dynamics in metabolic phenotype and gene expression in female mice.Hormones and behavior · 2025Article
- Estradiol metabolism by gut microbiota in women's depression pathogenesis: inspiration from nature.Frontiers in psychiatry · 2025Review
- The role of gonadal hormones in regulating opioid antinociception.Annals of medicine · 2024Review
- Subregion-specific transcriptomic profiling of rat brain reveals sex-distinct gene expression impacted by adolescent stress.Neuroscience · 2024Article
- Article
- Metabolic and feeding adjustments during pregnancy.Nature reviews. Endocrinology · 2023Review
- Association of Migraine and Vasomotor Symptoms.Mayo Clinic proceedings · 2023Article
- High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight.International journal of obesity (2005) · 2023Article
- RIIβ-PKA in GABAergic Neurons of Dorsal Median Hypothalamus Governs White Adipose Browning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Molecular identification of bulbospinal ON neurons by GPER, which drives pain and morphine tolerance.The Journal of clinical investigation · 2023Article
- Role of Estrogen Receptor α in Aging and Chronic Disease.Advances in geriatric medicine and research · 2023Article
- Centering the Needs of Transgender, Nonbinary, and Gender-Diverse Populations in Neuroendocrine Models of Gender-Affirming Hormone Therapy.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Review
- Estrogenic regulation of reproduction and energy homeostasis by a triumvirate of hypothalamic arcuate neurons.Journal of neuroendocrinology · 2022Review
- Implications of estrogen receptor alpha (ERa) with the intersection of organophosphate flame retardants and diet-induced obesity in adult mice.Journal of toxicology and environmental health. Part A · 2022Article
- Obesity I: Overview and molecular and biochemical mechanisms.Biochemical pharmacology · 2022Review
- Running the Female Power Grid Across Lifespan Through Brain Estrogen Signaling.Annual review of physiology · 2022Review
- Hypothalamic Kisspeptin Neurons and the Control of Homeostasis.Endocrinology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Contribution to Special Issue on Fast effects of steroids. There is now compelling evidence for membrane-associated estrogen receptors in hypothalamic neurons that are critical for the hypothalamic control of homeostatic functions. It has been known for some time that estradiol (E2) can rapidly alter hypothalamic neuronal activity within seconds, indicating that some cellular effects can occur via membrane initiated events. However, our understanding of how E2 signals via membrane-associated receptors and how these signals impact physiological functions is only just emerging. Thus, E2 can affect second messenger systems including calcium mobilization and a plethora of kinases to alter cell excitability and even gene transcription in hypothalamic neurons. One population of hypothalamic neurons, the anorexigenic proopiomelanocortin (POMC) neurons, has long been considered to be a target of E2's actions based on gene (Pomc) expression studies. However, we now know that E2 can rapidly alter POMC neuronal activity within seconds and activate several intracellular signaling cascades that ultimately affect gene expression, actions which are critical for maintaining sensitivity to insulin in metabolically stressed states. E2 also affects the orexigenic Neuropeptide Y/Agouti-related Peptide (NPY/AgRP) neurons in similarly rapid but antagonistic manner. Therefore, this review will summarize our current state of knowledge of how E2 signals via rapid membrane-initiated and intracellular signaling cascades in POMC and NPY/AgRP neurons to regulate energy homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.