ReviewHormones and behavior2018
Rapid effects of ovarian hormones in dorsal striatum and nucleus accumbens.
Review in Hormones and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05282277 (Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis), which is not on this map. Cited by 105 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis
Who cites it
105 citing papers in PubMed, 1 synthesis or guideline pooled it, 166 citations in OpenAlex.
- Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review.Pharmacological reviews · 2022Pooled it
- Dopamine and Temporal Discounting: Revisiting Pharmacology and Individual Differences.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Trial
- Effects of separate and combined estradiol and progesterone administration on fear extinction in healthy pre-menopausal women.Translational psychiatry · 2024Trial
- Dose-dependent effects of estrogen on prediction error related neural activity in the nucleus accumbens of healthy young women.Psychopharmacology · 2020Trial
- Targeting α5-GABAA receptors to restore dopamine system function in a translationally relevant model of perimenopausal psychosis.Psychopharmacology · 2026Article
- Sex-biased computations underlying differential set shift performance in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Impact of Circulating Estrogen and Mild Systemic Dehydration on Ultrasonic Vocalizations in Female Rats.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Ovarian hormonal state at exercise initiation interacts with nigrostriatal circuitry to determine long-term voluntary exercise behavior.bioRxiv : the preprint server for biology · 2026Article
- Sex and ovarian hormone cycles alter effects of stimulant drugs on mouse dopaminergic signaling.The Journal of clinical investigation · 2026Article
- Molecular Mechanisms of Menstrual Cycle-Related Suicide Risk: A Selective Review of Promising Candidate Systems.Biological psychiatry · 2026Review
- The Impact of Estradiol Dynamics During the Menopause Transition on Depression Risk: A Narrative Review of Estradiol's Neurobiological Mechanisms.Biological psychiatry · 2026Review
- Reproductive experience modifies the dopaminergic system of postpartum estrous rats: changes in the sensitivity to the behavioural effects of sch-23390 and in its receptors' binding.Psychopharmacology · 2026Article
- Linking brain structure to stress reactivity: cingulate surface area predicts acute cortisol responses.Psychological medicine · 2026Article
- Ovarian hormones, hormonal contraceptives and reward processing.BJPsych advances · 2026Article
- Estrogen modulates reward prediction errors and reinforcement learning.Nature neuroscience · 2025Article
- Beyond Hot Flashes: The Role of Estrogen Receptors in Menopausal Mental Health and Cognitive Decline.Brain sciences · 2025Review
- Sex Differences in the Striatal Contributions to Longitudinal Fine Motor Development in Autistic Children.Biological psychiatry · 2025Article
- Sex Differences in Histamine Regulation of Striatal Dopamine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- High ovarian hormones present during fear extinction reduce fear relapse through a nigrostriatal dopamine pathway.Biology of sex differences · 2025Article
- The effects of estradiol on subcortical brain volumes in perimenopausal-onset depression.Journal of affective disorders · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Contribution to Special Issue on Fast effects of steroids. Estradiol and progesterone rapidly induce changes in dopaminergic signaling within the dorsal striatum and nucleus accumbens of female rats. In ovariectomized females, estradiol rapidly enhances dopamine release and modulates binding of dopamine receptors. Progesterone further potentiates the effect of estradiol on dopamine release. The effects of both estradiol and progesterone are time course dependent, with increases in dopamine release immediately after acute hormone administration followed by later inhibition of dopamine release. Importantly, these changes are also seen in naturally cycling females, indicating their importance for normal physiological states and relevant reproductive behaviors. Here, we summarize the literature establishing the rapid effects of estradiol and progesterone on dopamine release and receptor expression in dorsal striatum and nucleus accumbens of both males and females. Integrating this literature with the larger body of work focusing on dopamine regulated behaviors, we propose hypotheses for adaptive reasons (i.e., ultimate causes) as to why changes in ovarian hormones modulate dopamine release. Finally, we note the importance of these studies for understanding sex differences in vulnerability to drug addiction. Research on how dopaminergic systems regulate behavior in both males and females is crucial for developing a full appreciation of dopamine's role in both natural and drug-induced behaviors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.