Observational studyPurinergic signalling2018
Uric acid levels are associated with endothelial dysfunction and severity of coronary atherosclerosis during a first episode of acute coronary syndrome.
Observational study in Purinergic signalling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed.
- Correlation of neutrophil/lymphocyte, monocyte/lymphocyte, and CRP/ALB ratios with the extent of coronary artery lesions and their predictive value.Frontiers in cardiovascular medicine · 2026Article
- J-shaped association of serum uric acid with all-cause and cardiovascular mortality in patients with diabetic kidney disease.Acta diabetologica · 2025Article
- Observational
- Prognostic role of the serum uric acid-to-serum creatinine ratio in patients with st-elevation myocardial infarction and multivessel coronary artery disease.Cardiology journal · 2025Article
- The influence of night shift work and associated factors on serum uric acid in aircraft maintenance workers.BMC public health · 2024Article
- Progress of uric acid in cardiovascular disease.Cardiovascular endocrinology & metabolism · 2024Review
- Interaction between CETP Taq1B polymorphism and dietary patterns on lipid profile and severity of coronary arteries stenosis in patients under coronary angiography: a cross-sectional study.Nutrition journal · 2023Article
- Associations between Sleep-Disordered Breathing and Serum Uric Acid and Their Sex Differences: The Nagahama Study.Nutrients · 2023Article
- Interaction of dietary patterns with rs28362491 on severity of coronary artery stenosis in patients undergoing coronary angiography.Scientific reports · 2023Article
- Hyperuricemia is associated with all-cause mortality among males and females: Findings from a study on Japanese community-dwelling individuals.Metabolism open · 2022Article
- Article
- Joint effects of paraoxonase 1 rs662 polymorphism and vitamins C/E intake on coronary artery disease severity (Gensini and SYNTAX scores) and lipid profile in patients undergoing coronary angiography.Frontiers in nutrition · 2022Article
- Per- and polyfluoroalkyl substance (PFAS) exposure, maternal metabolomic perturbation, and fetal growth in African American women: A meet-in-the-middle approach.Environment international · 2022Article
- The Potential of Prognostic Biomarkers of Uric Acid Levels in Coronary Heart Disease Among Aged Population: A Scoping Systematic Review of the Latest Cohort Evidence.Journal of multidisciplinary healthcare · 2022Article
- The association of the paraoxonase 1 Q192R polymorphism with coronary artery disease (CAD) and cardiometabolic risk factors in Iranian patients suspected of CAD.Frontiers in cardiovascular medicine · 2022Article
- Hyperuricemia and the small intestine: Transport mechanisms and co-morbidities.Biotechnology notes (Amsterdam, Netherlands) · 2022Review
- The Role of Uric Acid in Acute and Chronic Coronary Syndromes.Journal of clinical medicine · 2021Review
- Association between Serum Uric Acid and Pre-hypertension and Hypertension among Chinese Adults.Arquivos brasileiros de cardiologia · 2021Article
- Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?International journal of molecular sciences · 2021Review
- Adenosine and Its Receptors: An Expected Tool for the Diagnosis and Treatment of Coronary Artery and Ischemic Heart Diseases.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of serum uric acid in coronary artery disease has been extensively investigated. It was suggested that serum uric acid level (SUA) is an independent predictor of endothelial dysfunction and related to coronary artery lesions. However, the relationship between SUA and severity of coronary atherosclerosis evaluated via endothelial dysfunction using peripheral arterial tone (PAT) and the reactive hyperhemia index (RHI) has not been investigated during a first episode of acute coronary syndrome (ACS). The aim of our study was to address this point. We prospectively enrolled 80 patients with a first episode of ACS in a single-center observational study. All patients underwent coronary angiography, evaluation of endothelial function via the RHI, and SUA measurement. The severity of the coronary artery lesion was assessed angiographically, and patients were classified in three groups based on the extent of disease and Gensini and SYNTAX scores. Endothelial function was considered abnormal if RHI < 1.67. We identified a linear correlation between SUA and RHI (R
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