ArticleVirchows Archiv : an international journal of pathology2018
Interobserver variability in the H&E-based assessment of tumor budding in pT3/4 colon cancer: does it affect the prognostic relevance?
Article in Virchows Archiv : an international journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Direct tumour-adipocyte contact / Stroma AReactive Invasion Front Area (TAC/SARIFA) predicts adverse outcome in colorectal cancer: a focused evidence synthesis and meta-analysis.Histopathology · 2026Pooled it
- Immunohistochemical analysis of tumor budding in stage II colon cancer: exploring zero budding as a prognostic marker.Virchows Archiv : an international journal of pathology · 2024Article
- Novel biomarker SARIFA in colorectal cancer: highly prognostic, not genetically driven and histologic indicator of a distinct tumor biology.Cancer gene therapy · 2024Article
- Capsaicin and Cold exposure promote EMT-mediated premetastatic niche formation to facilitate colorectal cancer metastasis.Journal of Cancer · 2024Article
- Use of artificial intelligence in the management of T1 colorectal cancer: a new tool in the arsenal or is deep learning out of its depth?Clinical endoscopy · 2024Review
- Pathologist Validation of a Machine Learning-Derived Feature for Colon Cancer Risk Stratification.JAMA network open · 2023Article
- The promise and challenge of spatial omics in dissecting tumour microenvironment and the role of AI.Frontiers in oncology · 2023Review
- Alcohol promotes epithelial mesenchymal transformation-mediated premetastatic niche formation of colorectal cancer by activating interaction between laminin-γ2 and integrin-β1.World journal of gastroenterology · 2022Article
- Tumour-stroma ratio outperforms tumour budding as biomarker in colon cancer: a cohort study.International journal of colorectal disease · 2021Article
- Article
- Improving tumor budding reporting in colorectal cancer: a Delphi consensus study.Virchows Archiv : an international journal of pathology · 2021Review
- Prognostic value of tumor budding in gallbladder cancer: application of the International Tumor Budding Consensus Conference scoring system.Virchows Archiv : an international journal of pathology · 2021Article
- Deep Learning Prediction of Metastasis in Locally Advanced Colon Cancer Using Binary Histologic Tumor Images.Cancers · 2021Article
- Interpretable survival prediction for colorectal cancer using deep learning.NPJ digital medicine · 2021Article
- Reproducibility of tumor budding assessment in pancreatic cancer based on a multicenter interobserver study.Virchows Archiv : an international journal of pathology · 2021Article
- Analysis of Colorectal Carcinogenesis Paradigm between Cold Constitution and Heat Constitution: Earlier ECM Collagen Deposition.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Prognostic Significance of Lacunarity in Preoperative Biopsy of Colorectal Cancer.Pathology oncology research : POR · 2020Article
- Interobserver Variability in the Assessment of Tumor Budding in pT 3/4 Colon Cancer: Improvement by Supporting Immunohistochemistry?Diagnostics (Basel, Switzerland) · 2020Article
- Tumour budding and its clinical implications in gastrointestinal cancers.British journal of cancer · 2020Review
- Tumor proportion in colon cancer: results from a semiautomatic image analysis approach.Virchows Archiv : an international journal of pathology · 2020Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Tumor budding is a mostly accepted adverse prognostic factor in colorectal carcinoma. It is on the cusp of a widespread use after agreement was reached recently on uniform assessment criteria. We investigated whether the interobserver variability has a direct influence on the prognostic relevance in pT3/4 colon cancer in the background of different levels of experience of the investigators. In total, six investigators with different levels of experience evaluated tumor budding on H&E slides in 244 cases with primary diagnosed (2002-2011) colon carcinoma (pT3/4, N+/-, M0). High-grade tumor budding/budding grade 3 (defined as majority assessment among the investigators) was significantly associated with an adverse outcome (overall survival p = 0.03, cancer-specific survival p = 0.08) and the occurrence of distant metastasis (p = 0.009). However, a detailed analysis of the rating results of the individual investigators revealed that only ratings of one investigator (advanced resident) were associated with an adverse outcome (p = 0.01 cancer-specific survival, overall survival p = 0.09, distant metastasis p = 0.002). The results of another investigator (consultant) were significantly associated with distant metastasis (p = 0.007). The kappa values among the investigators have a range between 0.077 and 0.357 (median 0.166). Total agreement of all investigators existed in 109 cases (44.7%). Our results demonstrate that the evaluation of tumor budding on H&E slides in pT3/4 colon cancer goes along with a considerable interobserver variability among investigators of different levels of experience. Furthermore, our results reveal that these findings directly influence the prognostic value.
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