ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2018
Venous beading in two or more quadrants might not be a sensitive grading criterion for severe nonproliferative diabetic retinopathy.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Efficacy of conbercept pro re nata (PRN) versus treat-and-extend (T&E) regimens following five initial monthly doses in diabetic macular edema: a 24-month retrospective cohort study.Frontiers in endocrinology · 2026Article
- Mitigation of AI adoption bias through an improved autonomous AI system for diabetic retinal disease.NPJ digital medicine · 2024Article
- Prevalence of retinal pathologies in people over 60 years: the Tehran Geriatrics Eye Study.International journal of ophthalmology · 2024Article
- Intraretinal Microvascular Abnormalities and Venous Beading Have Different Genetic Profiles in Caucasian Patients with Non-Proliferative Diabetic Retinopathy.Vision (Basel, Switzerland) · 2023Article
- Retinal vein changes after treatment with aflibercept and PRP in high-risk proliferative diabetic retinopathy.Frontiers in medicine · 2023Article
- Comparison of fundus fluorescein angiography and fundus photography grading criteria for early diabetic retinopathy.International journal of ophthalmology · 2022Article
- Artificial intelligence in OCT angiography.Progress in retinal and eye research · 2021Review
- Differential distribution of manifest lesions in diabetic retinopathy by fundus fluorescein angiography and fundus photography.BMC ophthalmology · 2020Observational
- The unmet need for better risk stratification of non-proliferative diabetic retinopathy.Diabetic medicine : a journal of the British Diabetic Association · 2019Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo determine whether venous beading (VB) in two or more quadrants is an appropriate grading criterion for severe nonproliferative diabetic retinopathy (NPDR).
methodsA hospital-based, retrospective, cross-sectional study. A total of 806 patients admitted with diabetic retinopathy (DR) from January 2014 to April 2017 were included in this study. DR severity was graded by the international grading criterion. The status of VB, intraretinal microvascular abnormalities (IRMA), capillary nonperfusion, arteriovenous nicking, and diabetic macular edema was evaluated based on fundus fluorescein angiography.
resultsThe prevalence of VB in eyes with proliferative diabetic retinopathy (PDR), severe NPDR, and moderate NPDR was 41.3% (327/791), 5.9% (31/526), and 0% (0/295), respectively (p < 0.001). Moreover, the proportion of VB in two or more quadrants was even lower (27.1% for PDR and 2.1% for severe NPDR, p < 0.001), and among the total of 225 eyes with VB in two or more quadrants, 214 eyes (95.1%) were graded as PDR. Furthermore, VB formation was significantly correlated with capillary nonperfusion, duration of diabetes (both p < 0.001), and smoking (p < 0.05). After adjusting for age, sex, and other possible factors, VB (OR = 7.479, p < 0.001) and IRMA (OR = 2.433, p < 0.001) were determined as independent risk factors for developing PDR.
conclusionsOur study suggested that VB in two or more quadrants might not be a sensitive grading criterion for severe NPDR among a Chinese population with type 2 diabetes. Nevertheless, VB has a great specificity to define an advanced form of DR.
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