ArticleNature communications2018
De novo reconstruction of human adipose transcriptome reveals conserved lncRNAs as regulators of brown adipogenesis.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 73 citations in OpenAlex.
- A Feedforward Loop within the Thyroid-Brown Fat Axis Facilitates Thermoregulation.Scientific reports · 2020Trial
- CircadianiScience · 2026Article
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- Noncoding RNA profiling in omentum adipose tissue from obese patients and the identification of novel metabolic biomarkers.Frontiers in genetics · 2025Article
- A novel long noncoding RNA AK029592 contributes to thermogenic adipocyte differentiation.Stem cells translational medicine · 2024Article
- Review
- Transcriptomic analysis reveals regulation of adipogenesis via long non-coding RNA, alternative splicing, and alternative polyadenylation.Scientific reports · 2024Article
- Genome-wide identification and functional profile analysis of long non-coding RNAs in Avicennia marina.The plant genome · 2024Article
- Cold-inducible lncRNA266 promotes browning and the thermogenic program in white adipose tissue.EMBO reports · 2023Article
- Brown adipocyte and browning thermogenesis: metabolic crosstalk beyond mitochondrial limits and physiological impacts.Adipocyte · 2023Review
- The obesity-linked human lncRNA AATBC stimulates mitochondrial function in adipocytes.EMBO reports · 2023Article
- Genetics and epigenetics in the obesity phenotyping scenario.Reviews in endocrine & metabolic disorders · 2023Review
- Multidimensional conservation analysis decodes the expression of conserved long noncoding RNAs.Life science alliance · 2023Article
- Chordin-like 1, a Novel Adipokine, Markedly Promotes Adipogenesis and Lipid Accumulation.Cells · 2023Article
- Review
- Identification of thermogenesis-related lncRNAs in small extracellular vesicles derived from adipose tissue.BMC genomics · 2022Article
- Transcriptome Sequencing to Identify Important Genes and lncRNAs Regulating Abdominal Fat Deposition in Ducks.Animals : an open access journal from MDPI · 2022Article
- Article
- Brown adipose tissue thermogenesis among a small sample of reindeer herders from sub-Arctic Finland.Journal of physiological anthropology · 2022Article
- Transcriptomic profiling of the telomerase transformed Mesenchymal stromal cells derived adipocytes in response to rosiglitazone.BMC genomic data · 2022Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity has emerged as an alarming health crisis due to its association with metabolic risk factors such as diabetes, dyslipidemia, and hypertension. Recent work has demonstrated the multifaceted roles of lncRNAs in regulating mouse adipose development, but their implication in human adipocytes remains largely unknown. Here we present a catalog of 3149 adipose active lncRNAs, of which 909 are specifically detected in brown adipose tissue (BAT) by performing deep RNA-seq on adult subcutaneous, omental white adipose tissue and fetal BATs. A total of 169 conserved human lncRNAs show positive correlation with their nearby mRNAs, and knockdown assay supports a role of lncRNAs in regulating their nearby mRNAs. The knockdown of one of those, lnc-dPrdm16, impairs brown adipocyte differentiation in vitro and a significant reduction of BAT-selective markers in in vivo. Together, our work provides a comprehensive human adipose catalog built from diverse fat depots and establishes a roadmap to facilitate the discovery of functional lncRNAs in adipocyte development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.