Evidence map›Paper›PMID 29626152›Full record

ArticleJournal of the American Heart Association2018

"Summer Shift": A Potential Effect of Sunshine on the Time Onset of ST-Elevation Acute Myocardial Infarction.

Carlo Vittorio Cannistraci, Tuomo Nieminen, Masahiro Nishi, Levon M Khachigian, Juho Viikilä, Mika Laine, Domenico Cianflone, Attilio Maseri, Khung Keong Yeo, Ravinay Bhindi and 1 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Systemic effects of sunlight: 10-year review of cardiovascular, infection and cancer outcomes.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Review
  2. Article
  3. Article
  4. Self-Reported Outdoor Light Exposure Time and Incident Heart Failure.Journal of the American Heart Association · 2024
    Article
  5. Article
  6. Article
  7. Seasonal dynamics of myocardial infarctions in regions with different types of a climate: a meta-analysis.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2022
    Review
  8. Seasonal variation in blood pressure: current evidence and recommendations for hypertension management.Hypertension research : official journal of the Japanese Society of Hypertension · 2021
    Review
  9. Article
  10. Article
  11. Article
  12. Insufficient Sun Exposure Has Become a Real Public Health Problem.International journal of environmental research and public health · 2020
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 5 countries.

Carlo Vittorio CannistraciBiomedical Cybernetics Group, Biotechnology Center (BIOTEC), Center for Molecular and Cellular Bioengineering (CMCB), Center for Systems Biology Dresden (CSBD), Department of Physics, Technische Universität Dresden, Dresden, Germany kalokagathos.agon@gmail.com enrico.ammirati@ospedaleniguarda.it.
Tuomo NieminenInternal Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Masahiro NishiDepartment of Cardiology, Omihachiman Community Medical Center, Omihachiman, Japan.
Levon M KhachigianVascular Biology and Translational Research, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia.
Juho ViikiläCardiology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Mika LaineCardiology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Domenico CianfloneSan Raffaele Vita-Salute University and Hospital, Milan, Italy.
Attilio MaseriHeart Care Foundation, Florence, Italy.
Khung Keong YeoNational Heart Centre Singapore, Singapore.
Ravinay BhindiRoyal North Shore Hospital, Sydney, Australia.
Enrico AmmiratiDe Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy kalokagathos.agon@gmail.com enrico.ammirati@ospedaleniguarda.it.
Helsinki University Hospital · FIAssociazione Nazionale Medici Cardiologi Ospedalieri · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITCentro Neurolesi Bonino Pulejo · ITNational Heart Centre Singapore · SGRoyal North Shore Hospital · AUUniversity of Helsinki · FIUNSW Sydney · AUVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundST-elevation acute myocardial infarction (STEMI) represents one of the leading causes of death. The time of STEMI onset has a circadian rhythm with a peak during diurnal hours, and the occurrence of STEMI follows a seasonal pattern with a salient peak of cases in the winter months and a marked reduction of cases in the summer months. Scholars investigated the reason behind the winter peak, suggesting that environmental and climatic factors concur in STEMI pathogenesis, but no studies have investigated whether the circadian rhythm is modified with the seasonal pattern, in particular during the summer reduction in STEMI occurrence. METHODS AND

resultsHere, we provide a multiethnic and multination epidemiological study (from both hemispheres at different latitudes, n=2270 cases) that investigates whether the circadian variation of STEMI onset is altered in the summer season. The main finding is that the difference between numbers of diurnal (6:00 to 18:00) and nocturnal (18:00 to 6:00) STEMI is markedly decreased in the summer season, and this is a prodrome of a complex mechanism according to which the circadian rhythm of STEMI time onset seems season dependent.

conclusionsThe "summer shift" of STEMI to the nocturnal interval is consistent across different populations, and the sunshine duration (a measure related to cloudiness and solar irradiance) underpins this season-dependent circadian perturbation. Vitamin D, which in our results seems correlated with this summer shift, is also primarily regulated by the sunshine duration, and future studies should investigate their joint role in the mechanisms of STEMI etiogenesis.

Indexed as

RegistriesSeasonsCircadian RhythmElectrocardiographyFemaleFollow-Up StudiesGlobal HealthHumansIncidenceMaleMiddle AgedPercutaneous Coronary InterventionPrevalencePrognosisProspective StudiesST Elevation Myocardial Infarctionchronobiologycircadian rhythmepidemiologyrisk factorseasonal variationST‐segment elevation myocardial infarction

Identifiers

PMID29626152
PMCPMC6015398
OpenAlexW2795523309

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.