ArticleProceedings of the National Academy of Sciences of the United States of America2018
Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 252 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
252 citing papers in PubMed, 1 synthesis or guideline pooled it, 667 citations in OpenAlex.
- Molecular fluorophores for in vivo bioimaging in the second near-infrared window.European journal of nuclear medicine and molecular imaging · 2022Pooled it
- Randomized, Double-Blind, Controlled Study to Evaluate Safety and Pharmacokinetics of Single Ascending Doses of ASP5354, an Investigational Imaging Product, in Healthy Adult Volunteers.Clinical pharmacology in drug development · 2021Trial
- Donor-Acceptor Bridging via Twisted Quasi-Double-Bond: A Facile Design Strategy for Typical NIR-II AIEgen with "Simple" Structure.Chemical & biomedical imaging · 2026Article
- A compact, wireless fluorimeter system for continuous, real-time monitoring of tissue perfusion via in vivo fluorescence signals.Science advances · 2026Article
- Depth estimation from wavelength-dependent fluorescence spread profiles across NIR-I and NIR-II.Journal of biomedical optics · 2026Article
- Structural Engineering of Cyanine Dyes to Access Shortwave Infrared-Emissive J-Aggregates.Journal of the American Chemical Society · 2026Article
- C1'-Substituted Penta- and Heptamethine Cyanines: Synthetic Scope and Properties.The Journal of organic chemistry · 2026Article
- Silicon Flavylium Polymethine Dyes for Shortwave Infrared Imaging.Journal of the American Chemical Society · 2026Article
- Multispectral photoacoustic microscopy and NIR-II fluorescence imaging of TREM2-positive microglia in Aβ-driven Alzheimer's pathogenesis.Fundamental research · 2026Article
- Neural Network-Based Depth Retrieval of Fluorescent Targets From Wide-Field Fluorescence Intensity Images in Scattering Tissues.Journal of biophotonics · 2026Article
- Multiplexed optoacoustic tracking and magnetic actuation of labeled blood cells in living mice.Science advances · 2026Article
- Real-Time Detection of Burn Wound Infection via a Turn-On NIR-II Fluorescent Probe.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- De Novo Design of Near-Infrared Fluorescence-Activating Proteins.Journal of the American Chemical Society · 2026Article
- Engineering Nanoemulsions to Maximize NIR-II Fluorescence and Preserve Photothermal Performance of a Novel Boron Difluoride Formazanate Dye.Angewandte Chemie (International ed. in English) · 2026Article
- A renally clearable tumor-targeted probe enabling functional delineation of tumor margins by NIR-II fluorescence lifetime imaging.Materials today. Bio · 2026Article
- Counterion-Enhanced Brightness of Fluorous-Soluble Heptamethine Cyanine Dyes for Near- and Shortwave Infrared Fluorescence Imaging.Chemical & biomedical imaging · 2026Article
- Poly(3-hydroxybutyrate)-Based Biomimetic Materials Encapsulated with Amide Derivatives of Chlorin-e6 for Advanced Photodynamic Therapy.Nanomaterials (Basel, Switzerland) · 2026Article
- Chromenylium and Flavylium Polymethine Fluorophores Light Up the Shortwave Infrared Region.Accounts of chemical research · 2026Article
- Extended Fused Carbazole-BODIPY, High Brightness NIR Organic Dyes.Angewandte Chemie (International ed. in English) · 2026Article
- NIR Excitation in Atomically Precise Nanoclusters via Two-Photon and Three-Photon Absorption.Accounts of chemical research · 2026Article
192 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Fluorescence imaging is a method of real-time molecular tracking in vivo that has enabled many clinical technologies. Imaging in the shortwave IR (SWIR; 1,000-2,000 nm) promises higher contrast, sensitivity, and penetration depths compared with conventional visible and near-IR (NIR) fluorescence imaging. However, adoption of SWIR imaging in clinical settings has been limited, partially due to the absence of US Food and Drug Administration (FDA)-approved fluorophores with peak emission in the SWIR. Here, we show that commercially available NIR dyes, including the FDA-approved contrast agent indocyanine green (ICG), exhibit optical properties suitable for in vivo SWIR fluorescence imaging. Even though their emission spectra peak in the NIR, these dyes outperform commercial SWIR fluorophores and can be imaged in the SWIR, even beyond 1,500 nm. We show real-time fluorescence imaging using ICG at clinically relevant doses, including intravital microscopy, noninvasive imaging in blood and lymph vessels, and imaging of hepatobiliary clearance, and show increased contrast compared with NIR fluorescence imaging. Furthermore, we show tumor-targeted SWIR imaging with IRDye 800CW-labeled trastuzumab, an NIR dye being tested in multiple clinical trials. Our findings suggest that high-contrast SWIR fluorescence imaging can be implemented alongside existing imaging modalities by switching the detection of conventional NIR fluorescence systems from silicon-based NIR cameras to emerging indium gallium arsenide-based SWIR cameras. Using ICG in particular opens the possibility of translating SWIR fluorescence imaging to human clinical applications. Indeed, our findings suggest that emerging SWIR-fluorescent in vivo contrast agents should be benchmarked against the SWIR emission of ICG in blood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.