ArticleJournal of lipid research2018
Identification of unusual oxysterols and bile acids with 7-oxo or 3β,5α,6β-trihydroxy functions in human plasma by charge-tagging mass spectrometry with multistage fragmentation.
Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Cholesterol metabolism: from lipidomics to immunology.Journal of lipid research · 2022Review
- Cholesterol metabolism pathways - are the intermediates more important than the products?The FEBS journal · 2021Review
- HIGH RESOLUTION MASS SPECTROMETRY IN LIPIDOMICS.Mass spectrometry reviews · 2021Review
- Deep mining of oxysterols and cholestenoic acids in human plasma and cerebrospinal fluid: Quantification using isotope dilution mass spectrometry.Analytica chimica acta · 2021Article
- Coupling Machine Learning and Lipidomics as a Tool to Investigate Metabolic Dysfunction-Associated Fatty Liver Disease. A General Overview.Biomolecules · 2021Review
- Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates.The Journal of steroid biochemistry and molecular biology · 2021Article
- A concise review on lipidomics analysis in biological samples.ADMET & DMPK · 2021Review
- Recommendations for good practice in MS-based lipidomics.Journal of lipid research · 2021Review
- Quantification of common and planar bile acids in tissues and cultured cells.Journal of lipid research · 2020Article
- Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites.Prostaglandins & other lipid mediators · 2020Review
- Lipidomics from sample preparation to data analysis: a primer.Analytical and bioanalytical chemistry · 2020Review
- Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse.The Journal of steroid biochemistry and molecular biology · 2019Article
- Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders.Free radical biology & medicine · 2019Article
- Sterolomics in biology, biochemistry, medicine.Trends in analytical chemistry : TRAC · 2019Review
- Oxysterol research: a brief review.Biochemical Society transactions · 2019Review
- Developing an Enzyme-Assisted Derivatization Method for Analysis of CMolecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
7-Oxocholesterol (7-OC), 5,6-epoxycholesterol (5,6-EC), and its hydrolysis product cholestane-3β,5α,6β-triol (3β,5α,6β-triol) are normally minor oxysterols in human samples; however, in disease, their levels may be greatly elevated. This is the case in plasma from patients suffering from some lysosomal storage disorders, e.g., Niemann-Pick disease type C, or the inborn errors of sterol metabolism, e.g., Smith-Lemli-Opitz syndrome and cerebrotendinous xanthomatosis. A complication in the analysis of 7-OC and 5,6-EC is that they can also be formed ex vivo from cholesterol during sample handling in air, causing confusion with molecules formed in vivo. When formed endogenously, 7-OC, 5,6-EC, and 3β,5α,6β-triol can be converted to bile acids. Here, we describe methodology based on chemical derivatization and LC/MS with multistage fragmentation (MS
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Registered trials
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