Evidence map›Paper›PMID 29626090›Full record

ArticleThe Journal of biological chemistry2018

A GTPase-activating protein-binding protein (G3BP1)/antiviral protein relay conveys arteriosclerotic Wnt signals in aortic smooth muscle cells.

Bindu Ramachandran, John N Stabley, Su-Li Cheng, Abraham S Behrmann, Austin Gay, Li Li, Megan Mead, Julia Kozlitina, Andrew Lemoff, Hamid Mirzaei and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 37 citations in OpenAlex.

  1. The Role of Stress Granules in Cardiovascular Diseases.Reviews in cardiovascular medicine · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Connecting the Dots: Stress Granule and Cardiovascular Diseases.Journal of cardiovascular translational research · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Role(s) of G3BPs in Human Pathogenesis.The Journal of pharmacology and experimental therapeutics · 2023
    Review
  13. Review
  14. Review
  15. Review
  16. Pathophysiology of stress granules: An emerging link to diseases (Review).International journal of molecular medicine · 2022
    Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Bindu RamachandranDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
John N StableyDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Su-Li ChengDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Abraham S BehrmannDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Austin GayDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Li LiDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Megan MeadDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Julia KozlitinaEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Andrew LemoffDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Hamid MirzaeiDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Zhijian ChenDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Dwight A TowlerDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390. Electronic address: dwight.towler@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · USSouthwestern Medical Center · US

Funding

OSTEOGENIC REGULATION OF VASCULAR CALCIFICATIONR01HL069229 · NHLBI · WASHINGTON UNIVERSITY · PI TOWLER, DWIGHT A. · 2001 to 2022
$7.9M
Endocrine Regulation of Calcific Aortic Valve Sclerosis: PTH/PTHRP Receptor SignaR01HL114806 · NHLBI · WASHINGTON UNIVERSITY · PI TOWLER, DWIGHT A. · 2012 to 2016
$2.1M
Howard Hughes Medical InstituteNHLBI NIH HHS R01 HL069229NHLBI NIH HHS R01 HL114806
6 · The paper itself

Abstract

In aortic vascular smooth muscle (VSM), the canonical Wnt receptor LRP6 inhibits protein arginine (Arg) methylation, a new component of noncanonical Wnt signaling that stimulates nuclear factor of activated T cells (

Indexed as

Adaptor Proteins, Signal TransducingAnimalsAntiviral AgentsAortaArteriosclerosisbeta CateninCalcinosisCalciumCells, CulturedDNA HelicasesHumansLow Density Lipoprotein Receptor-Related Protein-6MiceMice, Inbred C57BLMice, KnockoutMyocytes, Smooth MuscleAdaptor Proteins, Signal TransducingAntiviral Agentsbeta CateninCalciumDNA HelicasesG3BP1 protein, humanLow Density Lipoprotein Receptor-Related Protein-6Lrp6 protein, mouseMAVS protein, mousePoly-ADP-Ribose Binding ProteinsReceptors, LDLRNA HelicasesRNA Recognition Motif ProteinsWnt Proteinsarteriosclerosisatherosclerosiscalcificationcardiovascular diseasemetabolic syndromeprotein methylationType 2 diabetesvascular biologyvascular smooth muscle cellsWnt signaling

Identifiers

PMID29626090
PMCPMC5971440
OpenAlexW2795933694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.