ArticleThe Journal of pharmacology and experimental therapeutics2018
The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(
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Article in The Journal of pharmacology and experimental therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
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28 citing papers in PubMed, 43 citations in OpenAlex.
- Orphan nuclear receptor 4A1 (NR4A1) and NR4A2 are endogenous regulators of CD71 and their ligands induce ferroptosis in breast cancer.Cell death & disease · 2025Article
- The Search for Disease Modification in Parkinson's Disease-A Review of the Literature.Life (Basel, Switzerland) · 2025Review
- Dual nuclear receptor 4A1 (NR4A1/NR4A2) ligands inhibit glioblastoma growth and target TWIST1.Molecular pharmacology · 2025Article
- The Nurr1 ligand indole acetic acid hydrazide loaded onto ZnFe2O4 nanoparticles suppresses proinflammatory gene expressions in SimA9 microglial cells.Scientific reports · 2024Article
- Natural products and synthetic analogs as selective orphan nuclear receptor 4A (NR4A) modulators.Histology and histopathology · 2024Review
- Comparative safety, pharmacokinetics, and off-target assessment of 1,1-bis(3'-indolyl)-1-(Toxicology research · 2024Article
- Article
- A novel NR4A2-HuR axis promotes pancreatic cancer growth and tumorigenesis that is inhibited by NR4A2 antagonists.American journal of cancer research · 2024Article
- Article
- Systems level analysis of sex-dependent gene expression changes in Parkinson's disease.NPJ Parkinson's disease · 2023Article
- A Nurr1 ligand C-DIM12 attenuates brain inflammation and improves functional recovery after intracerebral hemorrhage in mice.Scientific reports · 2022Article
- Transcriptional Regulation of the Synaptic Vesicle Protein Synaptogyrin-3 (International journal of molecular sciences · 2022Article
- Nuclear receptors of NR1 and NR4 subfamilies in the regulation of microglial functions and pathology.Pharmacology research & perspectives · 2021Review
- Astrocyte inflammatory signaling mediates α-synuclein aggregation and dopaminergic neuronal loss following viral encephalitis.Experimental neurology · 2021Article
- Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1.ACS chemical biology · 2021Article
- The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer.Molecular cancer research : MCR · 2021Review
- A Low-Cost, Autonomous Gait Detection and Estimation System for Analyzing Gait Impairments in Mice.Journal of healthcare engineering · 2021Article
- Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.Journal of medicinal chemistry · 2020Article
- NF-κB Signaling in Astrocytes Modulates Brain Inflammation and Neuronal Injury Following Sequential Exposure to Manganese and MPTP During Development and Aging.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer's Disease-related Pathogenesis.Aging and disease · 2020Review
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Authors and funding
10 authors at 3 institutions in 1 country.
Sean L HammondDepartment of Environmental and Radiological Health Sciences (S.L.H., K.A.P., L.G.H., E.H.R., R.B.T.) and Department of Electrical and Computer Engineering (P.D., E.C.), Colorado State University, Fort Collins, Colorado; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (X.L., S.S.); and Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.).
Katriana A PopichakDepartment of Environmental and Radiological Health Sciences (S.L.H., K.A.P., L.G.H., E.H.R., R.B.T.) and Department of Electrical and Computer Engineering (P.D., E.C.), Colorado State University, Fort Collins, Colorado; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (X.L., S.S.); and Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.).
Xi LiDepartment of Environmental and Radiological Health Sciences (S.L.H., K.A.P., L.G.H., E.H.R., R.B.T.) and Department of Electrical and Computer Engineering (P.D., E.C.), Colorado State University, Fort Collins, Colorado; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (X.L., S.S.); and Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.).
Lindsay G HuntDepartment of Environmental and Radiological Health Sciences (S.L.H., K.A.P., L.G.H., E.H.R., R.B.T.) and Department of Electrical and Computer Engineering (P.D., E.C.), Colorado State University, Fort Collins, Colorado; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (X.L., S.S.); and Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.).
Evan H RichmanDepartment of Environmental and Radiological Health Sciences (S.L.H., K.A.P., L.G.H., E.H.R., R.B.T.) and Department of Electrical and Computer Engineering (P.D., E.C.), Colorado State University, Fort Collins, Colorado; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (X.L., S.S.); and Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.).
Pranav U DamaleDepartment of Environmental and Radiological Health Sciences (S.L.H., K.A.P., L.G.H., E.H.R., R.B.T.) and Department of Electrical and Computer Engineering (P.D., E.C.), Colorado State University, Fort Collins, Colorado; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (X.L., S.S.); and Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.).
Edwin K P ChongDepartment of Environmental and Radiological Health Sciences (S.L.H., K.A.P., L.G.H., E.H.R., R.B.T.) and Department of Electrical and Computer Engineering (P.D., E.C.), Colorado State University, Fort Collins, Colorado; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (X.L., S.S.); and Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.).
Donald S BackosDepartment of Environmental and Radiological Health Sciences (S.L.H., K.A.P., L.G.H., E.H.R., R.B.T.) and Department of Electrical and Computer Engineering (P.D., E.C.), Colorado State University, Fort Collins, Colorado; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (X.L., S.S.); and Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.).
Stephen SafeDepartment of Environmental and Radiological Health Sciences (S.L.H., K.A.P., L.G.H., E.H.R., R.B.T.) and Department of Electrical and Computer Engineering (P.D., E.C.), Colorado State University, Fort Collins, Colorado; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (X.L., S.S.); and Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.).
Ronald B TjalkensDepartment of Environmental and Radiological Health Sciences (S.L.H., K.A.P., L.G.H., E.H.R., R.B.T.) and Department of Electrical and Computer Engineering (P.D., E.C.), Colorado State University, Fort Collins, Colorado; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas (X.L., S.S.); and Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.S.B.) ron.tjalkens@colostate.edu.
University of Colorado Anschutz Medical Campus · USTexas A&M University · USColorado State University · US
Funding
Neuroinflammation and developmental vulnerability to manganese toxicityR01ES021656 · NIEHS · COLORADO STATE UNIVERSITY · PI TJALKENS, RONALD · 2013 to 2022
$4.2MRole of Aryl Hydrocarbon Receptor in Microbiota-Colon Stem Cell InteractionsR01ES025713 · NIEHS · TEXAS A&M AGRILIFE RESEARCH · PI CHAPKIN, ROBERT STEPHEN, JAYARAMAN, ARUL · 2016 to 2020
$2.0MCell-specific expression of AAV-Nurr1 in a model of Parkinson's DiseaseF31NS096841 · NINDS · COLORADO STATE UNIVERSITY · PI HAMMOND, SEAN LEE · 2016 to 2017
$70kNIEHS NIH HHS R01 ES021656NIEHS NIH HHS R01 ES025713NINDS NIH HHS F31 NS096841
Abstract
The orphan nuclear receptor Nurr1 (also called nuclear receptor-4A2) regulates inflammatory gene expression in glial cells, as well as genes associated with homeostatic and trophic function in dopaminergic neurons. Despite these known functions of Nurr1, an endogenous ligand has not been discovered. We postulated that the activation of Nurr1 would suppress the activation of glia and thereby protect against loss of dopamine (DA) neurons after subacute lesioning with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Our previous studies have shown that a synthetic Nurr1 ligand, 1,1-bis(3'-indolyl)-1-(
Indexed as
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineActive Transport, Cell NucleusAnimalsBrainCell CountCell NucleusDopaminergic NeuronsGene Expression RegulationIndolesLigandsMaleMiceMice, Inbred C57BLNeurogliaNeuroprotective AgentsNF-kappa B1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineIndolesLigandsNeuroprotective AgentsNF-kappa BNuclear Receptor Subfamily 4, Group A, Member 2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.