ArticleParkinsonism & related disorders2018
Peripheral neuropathy is associated with more frequent falls in Parkinson's disease.
Article in Parkinsonism & related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Wearable Health Technology to Quantify the Functional Impact of Peripheral Neuropathy on Mobility in Parkinson's Disease: A Systematic Review.Sensors (Basel, Switzerland) · 2020Pooled it
- Application of Shear Wave Elastography in Assessing Peripheral Neuropathy in Parkinson's Disease.Brain sciences · 2026Article
- Gait as a quantitative indicator of the severity of chemotherapy-induced peripheral neuropathy: a pilot study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Multidimensional Characterization of Parkinson's Disease Subtypes Through Motor Neuron Excitability and Peripheral Immune Dynamics: Insights from F-Wave Modulation Metrics.Diagnostics (Basel, Switzerland) · 2025Article
- Noradrenergic cardiac denervation is associated with gait velocity in Parkinson disease: a dual ligand PET study.European journal of nuclear medicine and molecular imaging · 2024Article
- Large-fiber neuropathy in Parkinson's disease: a narrative review.Neurological research and practice · 2024Review
- Longitudinal evaluation of polyneuropathy in Parkinson's disease.Journal of neurology · 2024Article
- Imbalance and gait impairment in Parkinson's disease: discussing postural instability and ataxia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Composite measures of motor performance and self-efficacy are better determinants of postural instability and gait difficulties than individual clinical measures in Parkinson's disease.Parkinsonism & related disorders · 2023Article
- Peripheral neuropathy in Parkinson's disease: prevalence and functional impact on gait and balance.Brain : a journal of neurology · 2023Article
- The Effect of Anthropometric Shoes on Lactic Acid Reduction in Nurses: A Mixed-Methods Study from Indonesia.Journal of multidisciplinary healthcare · 2023Article
- The severity of corneal nerve loss differentiates motor subtypes in patients with Parkinson's disease.Therapeutic advances in neurological disorders · 2023Article
- Decreased vestibular efficacy contributes to abnormal balance in Parkinson's disease.Journal of the neurological sciences · 2022Article
- Movement disorders and neuropathies: overlaps and mimics in clinical practice.Journal of neurology · 2022Review
- The Impact of Footwear on Occupational Task Performance and Musculoskeletal Injury Risk: A Scoping Review to Inform Tactical Footwear.International journal of environmental research and public health · 2022Article
- Corneal nerve fiber loss relates to cognitive impairment in patients with Parkinson's disease.NPJ Parkinson's disease · 2021Article
- Potential use of corneal confocal microscopy in the diagnosis of Parkinson's disease associated neuropathy.Translational neurodegeneration · 2020Review
- Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson's disease.Journal of neuroinflammation · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
introductionPeripheral neuropathy is a common condition in the elderly that can affect balance and gait. Postural imbalance and gait difficulties in Parkinson's disease (PD), therefore, may stem not only from the primary neurodegenerative process but also from age-related medical comorbidities. Elucidation of the effects of peripheral neuropathy on these difficulties in PD is important to provide more targeted and effective therapy. The purpose of this study was to investigate the association between lower-limb peripheral neuropathy and falls and gait performance in PD while accounting for disease-specific factors.
methodsFrom a total of 140 individuals with PD, 14 male participants met the criteria for peripheral neuropathy and were matched 1:1 for Hoehn & Yahr stage and duration of disease with 14 male participants without peripheral neuropathy. All participants underwent fall (retrospectively) and gait assessment, a clinical evaluation, and [
resultsThe presence of peripheral neuropathy was significantly associated with more falls (50% vs. 14%, p = 0.043), as well as a shorter stride length (p = 0.011) and greater stride length variability (p = 0.004), which resulted in slower gait speed (p = 0.016) during level walking. There was no significant difference in nigrostriatal dopaminergic denervation, cortical and thalamic cholinergic denervation, and MDS-UPDRS motor examination scores between groups.
conclusionLower-limb peripheral neuropathy is significantly associated with more falls and gait difficulties in PD. Thus, treating such neuropathy may reduce falls and/or improve gait performance in PD.
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