ArticleJournal of physiological anthropology2018
Association of EGLN1 genetic polymorphisms with SpO
Article in Journal of physiological anthropology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Altitude of area of residence as a risk factor for stunting in children aged 0-60 months: A systematic review and meta-analysis.Dialogues in health · 2026Review
- Genome-wide association study reveals acute mountain sickness susceptibility in Chinese population.Molecular genetics and genomics : MGG · 2026Article
- Differences in prevalence arising from reference values for physiological and laboratory measurements used in studies of Tibetan highlanders and differences in study populations between the two studies.Journal of physiological anthropology · 2026Article
- Sex differences in genotype frequency and the risk of polycythemia associated with rs13419896 and rs2790859 among Tibetan highlanders living in Tsarang, Mustang, Nepal.Journal of physiological anthropology · 2024Article
- Transcriptomic signatures of severe acute mountain sickness during rapid ascent to 4,300 m.Frontiers in physiology · 2024Article
- Endocrine, inflammatory and immune responses and individual differences in acute hypobaric hypoxia in lowlanders.Scientific reports · 2023Article
- Individual variations and sex differences in hemodynamics and percutaneous arterial oxygen saturation (SpOJournal of physiological anthropology · 2022Article
- Individual variations and sex differences in hemodynamics with percutaneous arterial oxygen saturation (SpOJournal of physiological anthropology · 2020Article
- Effects of acute hypobaric hypoxia on thermoregulatory and circulatory responses during cold air exposure.Journal of physiological anthropology · 2020Article
- HSPA1A gene polymorphism rs1008438 is associated with susceptibility to acute mountain sickness in Han Chinese individuals.Molecular genetics & genomic medicine · 2020Article
- Neural network correlates of high-altitude adaptive genetic variants in Tibetans: A pilot, exploratory study.Human brain mapping · 2020Article
- Effect ofBioMed research international · 2020Article
- Transcriptomic Changes in Young Japanese Males After Exposure to Acute Hypobaric Hypoxia.Frontiers in genetics · 2020Article
- Genetic Analysis ofParkinson's disease · 2020Article
- Non-visual effects of diurnal exposure to an artificial skylight, including nocturnal melatonin suppression.Journal of physiological anthropology · 2019Article
- The Role of Salivary miR-134-3p and miR-15b-5p as Potential Non-invasive Predictors for Not Developing Acute Mountain Sickness.Frontiers in physiology · 2019Article
- Current health status and its risk factors of the Tsarang villagers living at high altitude in the Mustang district of Nepal.Journal of physiological anthropology · 2018Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRecent studies have explored various genetic and physiological factors related to high-altitude adaptation in highlander populations. However, the effects of single nucleotide polymorphisms (SNPs), influencing such adaptation, on physiological responses to hypobaric hypoxia have not been examined in lowlanders with lowlander ancestry. Thus, we aimed to investigate the association between SNPs around the EGLN1 genomic region, possibly involved in high-altitude adaptation, and physiological changes to hypobaric hypoxia exposure in a cohort of Japanese lowlanders.
methodsPhysiological data were obtained from 46 healthy Japanese male students under different atmospheric pressure conditions (equivalent to sea level and altitudes of 2500 and 4000 m). Genotypes of seven SNPs around EGLN1 were determined in all subjects by PCR-direct sequencing or TaqMan SNP genotyping assay.
resultsResults of the association study suggest that percutaneous arterial oxygen saturation (SpO
conclusionsOur findings suggest that rs12097901 and rs2790859 genotypes affect SpO
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