Evidence map›Paper›PMID 29625511›Full record

ArticleKorean circulation journal2018

Laboratory Markers in Incomplete Kawasaki Disease according to Coronary Artery Outcome.

Kee Soo Ha, Gi Young Jang, JungHwa Lee, Kwang Chul Lee, Chang Sung Son

Open access · hybridAbstract read
In one paragraph

Article in Korean circulation journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Kee Soo HaDepartment of Pediatrics, Korea University Guro Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-6753-5411
Gi Young JangDepartment of Pediatrics, Korea University Ansan Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-4831-1188
JungHwa LeeDepartment of Pediatrics, Korea University Guro Hospital, Seoul, Korea. leejmd@chol.com.ORCID https://orcid.org/0000-0002-6592-3653
Kwang Chul LeeDepartment of Pediatrics, Korea University Anam Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0003-3552-8721
Chang Sung SonDepartment of Pediatrics, Korea University Anam Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-5872-1378
Korea University Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesWe defined laboratory marker profiles typical of incomplete Kawasaki disease (iKD) during illness, especially with respect to the presence of a coronary artery abnormality such as coronary artery dilation or aneurysm.

methodsThis retrospective study examined the clinical and laboratory markers of patients with iKD over time, along with those of patients with complete KD (cKD) and febrile controls.

resultsOf 795 patients, 178 had iKD, 504 had cKD and 113 were febrile controls. During the transition from the acute to subacute phase, the age-adjusted hemoglobin levels and platelet counts were significantly lower and higher, respectively, in the subacute phase than in the acute phase in both iKD and cKD patients, which differed from those of febrile controls. Lower levels of acute and subacute age-adjusted hemoglobin levels in iKD patients (odds ratio [OR], 0.538 and 0.583; p=0.006 and 0.018, respectively) and higher subacute platelet counts in cKD patients (OR, 1.004; p=0.014) were correlated with the risk of coronary dilation. A higher acute neutrophil-to-lymphocyte ratio was associated with aneurysm only in cKD patients (OR, 1.059; p=0.044).

conclusionsThe iKD patients share KD-specific laboratory marker profiles in terms of complete blood cell counts and acute phase reactant levels with cKD patients. However, the factors predicting coronary dilation differ according to the phenotype; lower acute and subacute age-adjusted hemoglobin levels predict coronary dilation only in iKD patients.

Indexed as

BiomarkersCoronary artery diseaseMucocutaneous lymph node syndrome

Identifiers

PMID29625511
PMCPMC5889978
OpenAlexW2788250957

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.