ArticleInvestigative ophthalmology & visual science2018
An Anatomic Characterization of the Midbrain Near Response Neurons in the Macaque Monkey.
Article in Investigative ophthalmology & visual science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Exercise and visual training interventions for myopia in children and adolescents: a systematic review with a focus on near-far accommodation.Frontiers in public health · 2026Pooled it
- Investigations into the anatomical location, physiological function, clinical implications, and significance of the nucleus of Perlia.Acta neurologica Belgica · 2024Pooled it
- Cross-species lesion mapping links a midbrain circuit to vergence dysfunction.Brain : a journal of neurology · 2026Article
- Precerebellar paramedian tract cell groups connections: I. Oculomotor internuclear projections.Brain structure & function · 2025Article
- Neural Control of Vergence and Ocular Accommodation.Annual review of vision science · 2025Review
- Efferent compared to afferent neural substrates of the vergence eye movement system evoked via fMRI.Frontiers in neuroscience · 2024Article
- Diagnostic accuracy of a modularized, virtual-reality-based automated pupillometer for detection of relative afferent pupillary defect in unilateral optic neuropathies.Frontiers in ophthalmology · 2024Article
- Brainstem sources of input to the central mesencephalic reticular formation in the macaque.Experimental brain research · 2023Article
- Effect of convergence on the horizontal VOR in normal subjects and patients with peripheral and central vestibulopathy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- A Novel Tectal/Pretectal Population of Premotor Lens Accommodation Neurons.Investigative ophthalmology & visual science · 2022Article
- The Pupillary Light Reflex as a Biomarker of Concussion.Life (Basel, Switzerland) · 2021Article
- Macaque monkey trigeminal blink reflex circuits targeting levator palpebrae superioris motoneurons.The Journal of comparative neurology · 2021Article
- Cerebellar projections to the macaque midbrain tegmentum: Possible near response connections.Visual neuroscience · 2021Article
- Superior colliculus projections to target populations in the supraoculomotor area of the macaque monkey.Visual neuroscience · 2021Article
- Is Primate Lens Accommodation Unilaterally or Bilaterally Controlled?Investigative ophthalmology & visual science · 2020Article
- Pupil Size as a Window on Neural Substrates of Cognition.Trends in cognitive sciences · 2020Review
- Test-Retest Reliability of Functional Magnetic Resonance Imaging Activation for a Vergence Eye Movement Task.Neuroscience bulletin · 2020Article
- Pupillary light reflex circuits in the macaque monkey: the preganglionic Edinger-Westphal nucleus.Brain structure & function · 2020Article
- Pupillary light reflex circuits in the Macaque Monkey: the olivary pretectal nucleus.Brain structure & function · 2020Article
- Response Properties of Cells Within the Rostral Superior Colliculus of Strabismic Monkeys.Investigative ophthalmology & visual science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Purpose: These experiments were designed to reveal the location of the premotor neurons that have previously been designated physiologically as the midbrain near response cells controlling vergence, lens accommodation, and pupillary constriction in response to target distance. Methods: To identify this population, the fixed N2c strain of rabies virus was injected into the ciliary body of seven Macaca fascicularis monkeys. The virus was trans-synaptically transported to the brain. Following a 58- to 76-hour survival, animals were perfused with formalin fixative. After frozen sectioning, tissue was reacted to reveal the location of the infected populations by use of a monoclonal anti-rabies antibody. Another series of sections was processed to determine which of the rabies-positive cells were cholinergic motoneurons by use of an antibody to choline acetyl transferase. Results: At earlier time points, only cholinergic cells in the preganglionic Edinger-Westphal nucleus ipsilateral to the injection were labeled. At later time points, an additional population of noncholinergic, premotor cells was present. These were most numerous at the caudal end of the supraoculomotor area, where they formed a bilateral band, oriented mediolaterally immediately above the oculomotor nucleus. Rostral to this, a smaller bilateral population was located near the midline within the supraoculomotor area. Conclusions: Most lens preganglionic motoneurons are multipolar cells making up a continuous column within the Edinger-Westphal nucleus. A population of premotor cells that likely represents the midbrain near response cells is located in the supraoculomotor area. These cells are bilaterally distributed relative to the eye they control, and are most numerous caudally.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.