ArticleVirology2018
Dual Insect specific virus infection limits Arbovirus replication in Aedes mosquito cells.
Article in Virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.
- Effects of insect-specific viruses on transmission, infection, and replication of arboviruses in co-infected mosquitoes: a systematic review.Parasites & vectors · 2026Pooled it
- Vector competence acrossJournal of virology · 2026Review
- Exploration of viral diversity in Aedes mosquitoes employing different shotgun metagenomic data analysis pipelines.Virology journal · 2026Article
- Article
- Article
- Review
- Differences in metavirome among Aedes albopictus, Culex tritaeniorhynchus, and Anopheles sinensis in Jiangxi Province, China.Parasites & vectors · 2026Article
- Systemic infection with insect-specific viruses does not affect Plasmodium sporozoite formation in Anopheles mosquitoes.PLoS neglected tropical diseases · 2025Article
- Virome sequencing and analysis of Aedes aegypti and Aedes albopictus from ecologically different sites in the Philippines.Parasites & vectors · 2025Article
- Microbiome diversity in mosquitoes and sand flies: implications for vector competence.Parasites & vectors · 2025Review
- Molecular evidence of Wolbachia and Orthoflavivirus infection in field-collected mosquitoes in three provinces of Türkiye.Tropical medicine & international health : TM & IH · 2025Article
- Differential effect of acuteOne health (Amsterdam, Netherlands) · 2025Article
- The Temperature-Associated Effects of Rift Valley Fever Virus Infections in Mosquitoes and Climate-Driven Epidemics: A Review.Viruses · 2025Review
- Insect-specific viruses: transmission dynamics and biological control strategies against arboviruses.Frontiers in microbiology · 2025Review
- High throughput sequencing sheds light on the viral diversity in Aedes aegypti mosquitoes from Binh Thuan Province, Vietnam.PloS one · 2025Article
- Highly divergent and diverse viral community infecting sylvatic mosquitoes from Northeast Brazil.Journal of virology · 2024Article
- Eilat virus (EILV) causes superinfection exclusion against West Nile virus (WNV) in a strain-specific manner inThe Journal of general virology · 2024Article
- Biased virus transmission following sequential coinfection of Aedes aegypti with dengue and Zika viruses.PLoS neglected tropical diseases · 2024Article
- Viral Interference between the Insect-Specific Virus Brejeira and the Saint Louis Encephalitis Virus In Vitro.Viruses · 2024Article
- Influence of dengue virus serotypes on the abundance ofJournal of virology · 2024Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Aedes mosquitoes are vectors for many pathogenic viruses. Cell culture systems facilitate the investigation of virus growth in the mosquito vector. We found Zika virus (ZIKV) growth to be consistent in A. albopictus cells but hypervariable in A. aegypti cell lines. As a potential explanation of this variability, we tested the hypothesis that our cells harbored opportunistic viruses. We screened Aedes cell lines for the presence of insect specific viruses (ISVs), Cell-fusing agent virus (CFAV) and Phasi charoen-like virus (PCLV). PCLV was present in the ZIKV-growth-variable A. aegypti cell lines but absent in A. albopictus lines, suggesting that these ISVs may interfere with ZIKV growth. In support of this hypothesis, PCLV infection of CFAV-positive A. albopictus cells inhibited the growth of ZIKV, dengue virus and La Crosse virus. These data suggest ISV infection of cell lines can impact arbovirus growth leading to significant changes in cell permissivity to arbovirus infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.