Evidence map›Paper›PMID 29625083›Full record

ArticleThe American journal of medicine2018

Comparative Trends in Heart Disease, Stroke, and All-Cause Mortality in the United States and a Large Integrated Healthcare Delivery System.

Stephen Sidney, Michael E Sorel, Charles P Quesenberry, Marc G Jaffe, Matthew D Solomon, Mai N Nguyen-Huynh, Alan S Go, Jamal S Rana

Abstract readComparative Study
In one paragraph

Article in The American journal of medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Review
  7. Article
  8. Article
  9. Risk of Cardiometabolic Risk Factors in Women With and Without a History of Breast Cancer: The Pathways Heart Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. Mechanism-Based Cardiac Regeneration Strategies in Mammals.Frontiers in cell and developmental biology · 2021
    Review
  14. Article
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  16. Article
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stephen SidneyDivision of Research, Kaiser Permanente Northern California, Oakland. Electronic address: steve.sidney@kp.org.
Michael E SorelDivision of Research, Kaiser Permanente Northern California, Oakland.
Charles P QuesenberryDivision of Research, Kaiser Permanente Northern California, Oakland.
Marc G JaffeDepartment of Endocrinology, Kaiser Permanente Northern California, South San Francisco.
Matthew D SolomonDivision of Research, Kaiser Permanente Northern California, Oakland; Department of Cardiology, Kaiser Permanente Northern California, Oakland.
Mai N Nguyen-HuynhDepartment of Neurology, Kaiser Permanente Northern California, Walnut Creek.
Alan S GoDivision of Research, Kaiser Permanente Northern California, Oakland; Departments of Epidemiology, Biostatistics, and Medicine, University of California, San Francisco; Department of Health Research and Policy, Stanford University School of Medicine, Stanford, Calif.
Jamal S RanaDivision of Research, Kaiser Permanente Northern California, Oakland; Department of Cardiology, Kaiser Permanente Northern California, Oakland; Department of Medicine, University of California, San Francisco, San Francisco.

Funding

HMO Research Network Cardiovascular Research NetworkU19HL091179 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI GO, ALAN S · 2007 to 2011
$8.7M
Development of a Cardiovascular Surveillance System in the CVRNRC2HL101666 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI SIDNEY, STEPHEN · 2009 to 2010
$7.2M
NHLBI NIH HHS RC2 HL101666NHLBI NIH HHS U19 HL091179
6 · The paper itself

Abstract

objectivesHeart disease and stroke remain among the leading causes of death nationally. We examined whether differences in recent trends in heart disease, stroke, and total mortality exist in the United States and Kaiser Permanente Northern California (KPNC), a large integrated healthcare delivery system.

methodsThe main outcome measures were comparisons of US and KPNC total, age-specific, and sex-specific changes from 2000 to 2015 in mortality rates from heart disease, coronary heart disease, stroke, and all causes. The Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research data system was used to determine US mortality rates. Mortality rates for KPNC were determined from health system, Social Security vital status, and state death certificate databases.

resultsDeclines in age-adjusted mortality rates were noted in KPNC and the United States for heart disease (36.3% in KPNC vs 34.6% in the United States), coronary heart disease (51.0% vs 47.9%), stroke (45.5% vs 38.2%), and all-cause mortality (16.8% vs 15.6%). However, steeper declines were noted in KPNC than the United States among those aged 45 to 65 years for heart disease (48.3% KPNC vs 23.6% United States), coronary heart disease (55.6% vs 35.9%), stroke (55.8% vs 26.0%), and all-cause mortality (31.5% vs 9.1%). Sex-specific changes were generally similar.

conclusionsDespite significant declines in heart disease and stroke mortality, there remains an improvement gap nationally among those aged less than 65 years when compared with a large integrated healthcare delivery system. Interventions to improve cardiovascular mortality in the vulnerable middle-aged population may play a key role in closing this gap.

Indexed as

MortalityAdultAgedAge FactorsCaliforniaCoronary DiseaseDelivery of Health Care, IntegratedFemaleHeart DiseasesHumansMaleMiddle AgedSex FactorsStrokeUnited StatesHeart diseaseMortality rateStroke

Identifiers

PMID29625083
PMCPMC6005733

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.