ArticleCell2018
Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.
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Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 230 papers.
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230citing papers in PubMed
21.0field-weighted citation impact, top 1% of its field
What it found
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Who cites it
230 citing papers in PubMed, 429 citations in OpenAlex.
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- Precision oncology in gynecologic cancers: molecular taxonomy, biomarker-guided therapeutics, and the challenge of therapeutic resistance.Frontiers in oncology · 2026Review
- Multi-omics driven computational framework for cancer molecular subtype classification.Scientific reports · 2025Article
- Precision Oncology: Current Landscape, Emerging Trends, Challenges, and Future Perspectives.Cells · 2025Review
170 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
35 authors at 16 institutions in 5 countries.
Li DingDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA; Department of Genetics, Washington University in St. Louis, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA. Electronic address: lding@wustl.edu.
Matthew H BaileyDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA.
Eduard Porta-PardoBarcelona Supercomputing Centre, 08034 Barcelona, Spain; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Vesteinn ThorssonInstitute for Systems Biology, Seattle, WA 98109, USA.
Antonio ColapricoMachine Learning Group (MLG), Département d'Informatique, Université Libre de Bruxelles, 1050 Brussels, Belgium; Department of Human Genetics, University of Miami, Miami, FL 33136, USA.
Denis BertrandComputational and Systems Biology, Genome Institute of Singapore, Singapore, 13862.
David L GibbsInstitute for Systems Biology, Seattle, WA 98109, USA.
Amila WeerasingheDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA.
Kuan-Lin HuangDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA.
Collin TokheimInstitute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Isidro Cortés-CirianoHarvard Medical School, Boston, MA 02115, USA; Ludwig Center at Harvard, Boston, MA 02115, USA; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Reyka JayasingheDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA.
Feng ChenDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA.
Lihua YuH3 Biomedicine Inc., Cambridge, MA 02139, USA.
Sam SunDepartment of Radiation Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
Catharina OlsenMachine Learning Group (MLG), Département d'Informatique, Université Libre de Bruxelles, 1050 Brussels, Belgium.
Jaegil KimBroad Institute, Cambridge, MA 02142, USA.
Alison M TaylorBroad Institute, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
Andrew D CherniackBroad Institute, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
Rehan AkbaniDepartment of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77498, USA.
Chayaporn SuphavilaiComputational and Systems Biology, Genome Institute of Singapore, Singapore, 13862.
Niranjan NagarajanComputational and Systems Biology, Genome Institute of Singapore, Singapore, 13862.
Joshua M StuartBaskin School of Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Gordon B MillsDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77498, USA.
Matthew A WyczalkowskiDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA.
Benjamin G VincentLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Curriculum in Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
Carolyn M HutterNational Human Genome Research Institute, Bethesda, MD 20892, USA.
Jean Claude ZenklusenNational Cancer Institute, Bethesda, MD 20892, USA.
Katherine A HoadleyLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Michael C WendlDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA; Department of Genetics, Washington University in St. Louis, St. Louis, MO 63110, USA.
Llya ShmulevichInstitute for Systems Biology, Seattle, WA 98109, USA.
Alexander J LazarDepartments of Pathology, Genomic Medicine, and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77498, USA.
David A WheelerDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA; Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: wheeler@bcm.edu.
Gad GetzHarvard Medical School, Boston, MA 02115, USA; Broad Institute, Cambridge, MA 02142, USA; Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: gadgetz@broadinstitute.org.
Cancer Genome Atlas Research Network
James S. McDonnell Foundation · USBroad Institute · USThe University of Texas MD Anderson Cancer Center · USInstitute for Systems Biology · USBaylor College of Medicine · USGenome Institute of Singapore · SGUniversity of North Carolina at Chapel Hill · USWashington University in St. Louis · USNational Cancer Institute · USNational Human Genome Research Institute · USUniversité Libre de Bruxelles · BEUniversity of California, Santa Cruz · USDana-Farber Cancer Institute · USHarvard University · USJohns Hopkins University · USSanford Burnham Prebys Medical Discovery Institute · US
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MLarge Scale Genome SequencingU54HG003079 · NHGRI · WASHINGTON UNIVERSITY · PI DUTCHER, SUSAN K · 2004 to 2016
$445.7MThe Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3MTumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8MVirology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3MGene Expression Patterns in Human Tumors Identified Using Transcript SequencingU24CA143848 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAYES, DAVID N, PEROU, CHARLES M · 2009 to 2016
$20.8MGenome Characterization Center (GCC)U24CA143867 · NCI · BROAD INSTITUTE, INC. · PI GABRIEL, STACEY, MEYERSON, MATTHEW L. · 2009 to 2016
$17.0MThe Cancer Genome Atlas Data Analysis CenterU24CA143845 · NCI · BROAD INSTITUTE, INC. · PI CHIN, LYNDA, GETZ, GAD A · 2009 to 2016
$16.0MHarvard Genome Characterization CenterU24CA144025 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI KUCHERLAPATI, RAJU S. · 2009 to 2016
$14.0MThe USC-JHU Cancer Epigenome Characterization CenterU24CA143882 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BAYLIN, STEPHEN B., WEISENBERGER, DANIEL JOSEPH · 2009 to 2016
$13.3MMSKCC Center for Translational Cancer Genomic AnalysisU24CA143840 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LADANYI, MARC, SANDER, CHRIS · 2009 to 2016
$11.5MNCI NIH HHS P30 CA016086NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA163722NCI NIH HHS R50 CA221675NCI NIH HHS U24 CA143799NCI NIH HHS U24 CA143835NCI NIH HHS U24 CA143840NCI NIH HHS U24 CA143843NCI NIH HHS U24 CA143845NCI NIH HHS U24 CA143848NCI NIH HHS U24 CA143858NCI NIH HHS U24 CA143866NCI NIH HHS U24 CA143867NCI NIH HHS U24 CA143882NCI NIH HHS U24 CA143883NCI NIH HHS U24 CA144025NCI NIH HHS U24 CA210949NCI NIH HHS U24 CA210950NCI NIH HHS U24 CA210957NCI NIH HHS U24 CA210974NCI NIH HHS U24 CA210988NCI NIH HHS U24 CA210990NCI NIH HHS U24 CA211006NHGRI NIH HHS U54 HG003067NHGRI NIH HHS U54 HG003079NHGRI NIH HHS U54 HG003273NIDA NIH HHS R25 DA027995NIEHS NIH HHS P30 ES010126
Abstract
The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we present our current understanding of the molecular processes governing oncogenesis. We illustrate our insights into cancer through synthesis of the findings of the TCGA PanCancer Atlas project on three facets of oncogenesis: (1) somatic driver mutations, germline pathogenic variants, and their interactions in the tumor; (2) the influence of the tumor genome and epigenome on transcriptome and proteome; and (3) the relationship between tumor and the microenvironment, including implications for drugs targeting driver events and immunotherapies. These results will anchor future characterization of rare and common tumor types, primary and relapsed tumors, and cancers across ancestry groups and will guide the deployment of clinical genomic sequencing.
Indexed as
GenomicsCarcinogenesisDatabases, GeneticDNA RepairGenes, NeoplasmHumansMetabolic Networks and PathwaysMicrosatellite InstabilityMutationNeoplasmsTranscriptomeTumor Microenvironmentcancercancer genomicsomicsoncogenic processTCGA
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