Evidence map›Paper›PMID 29624921›Full record

ArticleMolecular genetics & genomic medicine2018

A genetic variant in IL-15Rα correlates with physical activity among European-American adults.

Michael Bruneau, Sean Walsh, Eric Selinsky, Garrett Ash, Theodore J Angelopoulos, Priscilla Clarkson, Paul Gordon, Niall Moyna, Paul Visich, Robert Zoeller and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics & genomic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Genetic variants related to physical activity or sedentary behaviour: a systematic review.The international journal of behavioral nutrition and physical activity · 2021
    Pooled it
  2. Metabolic health disparities driven by financial stress: Behavioural adaptation or modification?Stress and health : journal of the International Society for the Investigation of Stress · 2023
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Michael BruneauDrexel University, Philadelphia, PA, USA.ORCID 0000-0002-4588-1468
Sean WalshCentral Connecticut State University, New Britain, CT, USA.
Eric SelinskyUniversity of Connecticut, Storrs, CT, USA.
Garrett AshYale University, New Haven, CT, USA.
Theodore J AngelopoulosEmory & Henry College, Emory, VA, USA.
Priscilla ClarksonUniversity of Massachusetts, Amherst, MA, USA.
Paul GordonBaylor University, Waco, TX, USA.
Niall MoynaDublin City University, Dublin, Ireland.
Paul VisichUniversity of New England, Biddeford, ME, USA.
Robert ZoellerFlorida Atlantic University, Boca Raton, FL, USA.
Paul ThompsonHartford Hospital, Hartford, CT, USA.
Heather Gordish-DressmanChildren's National Medical Center, Washington, DC, USA.
Eric HoffmanCooperative International Neuromuscular Research Group, Washington, DC, USA.
Joseph DevaneyChildren's National Medical Center, Washington, DC, USA.
Linda S PescatelloUniversity of Connecticut, Storrs, CT, USA.

Funding

Functional SNP's Assoc with Human Muscle Size &StrengthR01NS040606 · NINDS · CHILDREN'S RESEARCH INSTITUTE · PI HOFFMAN, ERIC P · 2001 to 2004
$4.7M
Multidisciplinary Behavioral Research Training in T1DT32DK097718 · NIDDK · YALE UNIVERSITY · PI GREY, MARGARET, WEINZIMER, STUART ALAN · 2012 to 2017
$771k
NIDDK NIH HHS T32 DK097718NINDS NIH HHS R01 NS040606
6 · The paper itself

Abstract

backgroundInterleukin-15 (IL-15) is a myokine associated with muscle strength, possibly by attenuating protein breakdown. A variant in the alpha-receptor (IL-15Rα 1775 A>C, rs2228059) partially modulates the muscle strength and size response to resistance training. We examined if this polymorphism associated with habitual physical activity among European-American adults.

methodsMen (n = 240, 23.7 ± 0.3 year, body mass index [BMI] 25.3 ± 0.3 kg/m

resultsMen with the IL-15Rα 1775AA genotype spent more time in light intensity physical activity (39.4 ± 2.4 hr/week) than men with the CC genotype (28.6 ± 2.3 hr/week, (p = .009).

conclusionFurther research is needed to confirm our finding and determine the possible mechanisms by which the IL-15Rα variant modulates light intensity physical activity.

Indexed as

AdultAllelesBody CompositionBody Mass IndexExerciseFemaleGene FrequencyGenetic VariationGenotypeHumansInterleukin-15Interleukin-15 Receptor alpha SubunitMaleMuscle, SkeletalMuscle StrengthPhenotypeInterleukin-15Interleukin-15 Receptor alpha Subunitcytokineexercisepolymorphisms

Identifiers

PMID29624921
PMCPMC6014439

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.