Evidence map›Paper›PMID 29624902›Full record

ArticleJournal of diabetes investigation2018

One-hour oral glucose tolerance test plasma glucose at gestational diabetes diagnosis is a common predictor of the need for insulin therapy in pregnancy and postpartum impaired glucose tolerance.

Takeshi Nishikawa, Keiko Ono, Shoko Hashimoto, Hiroyuki Kinoshita, Takuro Watanabe, Hirotaka Araki, Kae Otsu, Wakana Sakamoto, Masahiro Harada, Tetsushi Toyonaga and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of diabetes investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. The use of machine learning to predict pharmacological therapy in gestational diabetes: A scoping review.Diabetic medicine : a journal of the British Diabetic Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Takeshi NishikawaDepartment of Diabetes and Endocrinology, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan.ORCID http://orcid.org/0000-0003-2528-8963
Keiko OnoDepartment of Diabetes and Endocrinology, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan.
Shoko HashimotoDepartment of Diabetes and Endocrinology, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan.
Hiroyuki KinoshitaDepartment of Diabetes and Endocrinology, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan.
Takuro WatanabeDepartment of Diabetes and Endocrinology, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan.
Hirotaka ArakiDepartment of Diabetes and Endocrinology, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan.
Kae OtsuDepartment of Diabetes and Endocrinology, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan.
Wakana SakamotoDepartment of Diabetes and Endocrinology, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan.
Masahiro HaradaDepartment of Diabetes and Endocrinology, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan.
Tetsushi ToyonagaKikuchi Medical Association Hospital, Kikuchi, Japan.
Shoichi KawakamiFukuda Hospital, Kumamoto, Japan.
Jyunichiro FukudaFukuda Hospital, Kumamoto, Japan.
Yoshio HagaAmakusa Central General Hospital, Amakusa, Japan.
Daisuke KukidomeFaculty of Life Sciences, Department of Metabolic Medicine, Kumamoto University, Kumamoto, Japan.ORCID http://orcid.org/0000-0002-8414-8349
Takeshi TakahashiDepartment of Diabetes and Endocrinology, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan.
Eiich ArakiFaculty of Life Sciences, Department of Metabolic Medicine, Kumamoto University, Kumamoto, Japan.
Kumamoto Medical Center · JPFukuda Denshi (Japan) · JPKumamoto University · JPHakodate Central General Hospital · JPJapan Hospital Association · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIMS/

introductionGestational diabetes mellitus (GDM) is a risk for adverse perinatal outcomes, and patients with a history of GDM have an increased risk of impaired glucose tolerance (IGT). Here, we carried out two non-interventional and retrospective studies of GDM patients in Japan. MATERIALS AND

methodsIn the first study, we enrolled 529 GDM patients and assessed predictors of the need for insulin therapy. In the second study, we enrolled 185 patients from the first study, and assessed predictors of postpartum IGT.

resultsIn the first study, gestational weeks at GDM diagnosis and history of pregnancy were significantly lower, and pregestational body mass index, family history of diabetes mellitus, 1- and 2-h glucose levels in a 75-g oral glucose tolerance test (OGTT), the number of abnormal values in a 75-g OGTT, and glycated hemoglobin were significantly higher in participants receiving insulin therapy. In the second study, 1- and 2-h glucose levels in a 75-g OGTT, the number of abnormal values in a 75-g OGTT, glycated hemoglobin, and ketone bodies in a urine test were significantly higher in participants with OGT. Logistic regression analysis showed that gestational weeks at GDM diagnosis, 1-h glucose levels in a 75-g OGTT and glycated hemoglobin were significant predictors of the need for insulin therapy, and 1-h glucose levels in a 75-g OGTT at diagnosis and ketone bodies in a urine test were significant predictors for postpartum IGT.

conclusionsAntepartum 1-h glucose levels in a 75-g OGTT was a predictor of the need for insulin therapy in pregnancy and postpartum IGT.

Indexed as

AdultBlood GlucoseDiabetes, GestationalFemaleGestational AgeGlucose IntoleranceGlucose Tolerance TestHumansHypoglycemic AgentsInsulinJapanPostpartum PeriodPregnancyRetrospective StudiesRisk FactorsBlood GlucoseHypoglycemic AgentsInsulinGestational diabetesGlucose toleranceInsulin

Identifiers

PMID29624902
PMCPMC6215946
OpenAlexW2795839266

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.