Evidence map›Paper›PMID 29624727›Full record

ArticleMagnetic resonance in medicine2018

AutoVOI: real-time automatic prescription of volume-of-interest for single voxel spectroscopy.

Young Woo Park, Dinesh K Deelchand, James M Joers, Brian Hanna, Adam Berrington, Joseph S Gillen, Kejal Kantarci, Brian J Soher, Peter B Barker, HyunWook Park and 2 more

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Article
  3. A Fast and Precise Method to Search for Desirable Rectangular Tumor Regions in Brain MR Images.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
    Article
  4. Neurobiology of aging · 2026
    Article
  5. Article
  6. Article
  7. Sensitivity of Advanced Magnetic Resonance Imaging to Progression over Six Months in Early Spinocerebellar Ataxia.Movement disorders : official journal of the Movement Disorder Society · 2024
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Plug-and-play advanced magnetic resonance spectroscopy.Magnetic resonance in medicine · 2022
    Article
  20. Neurobiology of aging · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Young Woo ParkSchool of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Dinesh K DeelchandCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota.
James M JoersCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota.
Brian HannaCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota.
Adam BerringtonRussell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Joseph S GillenRussell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Kejal KantarciDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Brian J SoherDepartment of Radiology, Duke University Medical Center, Durham, North Carolina.
Peter B BarkerRussell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
HyunWook ParkSchool of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Gülin ÖzCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota.
Christophe LengletCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota.

Funding

THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
Longitudinal Imaging Biomarkers of Prodromal DLBU01NS100620 · NINDS · MAYO CLINIC ROCHESTER · PI Bradley F Boeve, KEJAL KANTARCI · 2017 to 2026
$19.2M
Prevention of Alzheimer's disease in women: risks and benefits of hormone therapyRF1AG057547 · NIA · MAYO CLINIC ROCHESTER · PI GLEASON, CAREY E, KANTARCI, KEJAL · 2017 to 2020
$11.1M
NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
Partnership for Magnetic Resonance Spectroscopy Biomarker Development-SupplementR01NS080816 · NINDS · UNIVERSITY OF MINNESOTA · PI OZ, GULIN · 2015 to 2019
$3.2M
Magnetic Resonance Spectroscopy Biomarkers of NeurodegenerationR01NS070815 · NINDS · UNIVERSITY OF MINNESOTA · PI OZ, GULIN · 2010 to 2014
$1.6M
Pathological basis of MRS and DTI changes in neurodegenerative dementiaR01AG040042 · NIA · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2011 to 2015
$1.6M
High Performance Connectome Upgrade for Human 3T MR ScannerS10OD017974 · OD · UNIVERSITY OF MINNESOTA · PI LIM, KELVIN O. · 2014 to 2014
$600k
NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG040042NIA NIH HHS RF1 AG057547NIBIB NIH HHS P41 EB015894NIH HHS S10 OD017974NINDS NIH HHS P30 NS076408NINDS NIH HHS R01 NS070815NINDS NIH HHS R01 NS080816NINDS NIH HHS U01 NS100620
6 · The paper itself

Abstract

purposeTo develop a fast and automated volume-of-interest (VOI) prescription pipeline (AutoVOI) for single-voxel MRS that removes the need for manual VOI placement, allows flexible VOI planning in any brain region, and enables high inter- and intra-subject consistency of VOI prescription.

methodsAutoVOI was designed to transfer pre-defined VOIs from an atlas to the 3D anatomical data of the subject during the scan. The AutoVOI pipeline was optimized for consistency in VOI placement (precision), enhanced coverage of the targeted tissue (accuracy), and fast computation speed. The tool was evaluated against manual VOI placement using existing T

resultsThe AutoVOI pipeline includes skull stripping, non-linear registration of the atlas to the subject's brain, and computation of the VOI coordinates and angulations using a minimum oriented bounding box algorithm. When compared against manual prescription, AutoVOI showed higher intra- and inter-subject spatial consistency, as quantified by generalized Dice coefficients (GDC), lower intra- and inter-subject variability in tissue composition (gray matter, white matter, and cerebrospinal fluid) and higher or equal accuracy, as quantified by GDC of prescribed VOI with targeted tissues. High quality spectra were obtained on Siemens and Philips 3T systems from 6 automatically prescribed VOIs by the tool.

conclusionRobust automatic VOI prescription is feasible and can help facilitate clinical adoption of MRS by avoiding operator dependence of manual selection.

Indexed as

AdultAlgorithmsBrainFemaleHumansImaging, Three-DimensionalMagnetic Resonance ImagingMaleYoung Adultautomationgeneralized dice coefficientMRSprescriptionregistration

Identifiers

PMID29624727
PMCPMC6107418

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.