Evidence map›Paper›PMID 29624641›Full record

Trial reportCancer2018

Feasibility, safety, and efficacy of aerobic training in pretreated patients with metastatic breast cancer: A randomized controlled trial.

Jessica M Scott, Neil M Iyengar, Tormod S Nilsen, Meghan Michalski, Samantha M Thomas, James Herndon, John Sasso, Anthony Yu, Sarat Chandarlapaty, Chau T Dang and 4 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  4. Effect of therapeutic exercise on peak oxygen consumption in oncological population: a systematic review with meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  5. Non-pharmacological interventions targeting mobility among people with advanced cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
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  7. Efficacy of Exercise Therapy on Cardiorespiratory Fitness in Patients With Cancer: A Systematic Review and Meta-Analysis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018
    Pooled it
  8. Experiences of patients with metastatic colorectal cancer participating in a supervised exercise intervention during chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jessica M ScottMemorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-4845-5800
Neil M IyengarMemorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-9773-5235
Tormod S NilsenDepartment of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.
Meghan MichalskiMemorial Sloan Kettering Cancer Center, New York, New York.
Samantha M ThomasDuke University Medical Center, Durham, North Carolina.
James HerndonDuke University Medical Center, Durham, North Carolina.
John SassoCentre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada.
Anthony YuMemorial Sloan Kettering Cancer Center, New York, New York.
Sarat ChandarlapatyMemorial Sloan Kettering Cancer Center, New York, New York.
Chau T DangMemorial Sloan Kettering Cancer Center, New York, New York.
Elizabeth A ComenMemorial Sloan Kettering Cancer Center, New York, New York.
Maura N DicklerMemorial Sloan Kettering Cancer Center, New York, New York.
Jeffrey M PeppercornMassachusetts General Hospital Cancer Center, Boston, Massachusetts.
Lee W JonesMemorial Sloan Kettering Cancer Center, New York, New York.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Phase II Trial of Aerobic Training in Metastatic Breast CancerR21CA143254 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JONES, LEE W · 2010 to 2012
$536k
NCI NIH HHS P30 CA008748NCI NIH HHS R21 CA143254
6 · The paper itself

Abstract

backgroundThe investigation of exercise training in metastatic breast cancer has received minimal attention. This study determined the feasibility and safety of aerobic training in metastatic breast cancer.

methodsSixty-five women (age, 21-80 years) with metastatic (stage IV) breast cancer (57% were receiving chemotherapy, and >40% had ≥ 2 lines of prior therapy) were allocated to an aerobic training group (n = 33) or a stretching group (n = 32). Aerobic training consisted of 36 supervised treadmill walking sessions delivered thrice weekly between 55% and 80% of peak oxygen consumption (VO

resultsOne of the 33 patients (3%) receiving aerobic training was LTF, whereas the mean attendance rate was 63% ± 30%. The rates of permanent discontinuation and dose modification were 27% and 49%, respectively. Intention-to-treat analyses indicated improvements in PROs, which favored the attention control group (P values > .05). Per protocol analyses indicated that 14 of 33 patients (42%) receiving aerobic training had acceptable tolerability (relative dose intensity ≥ 70%), and this led to improvements in VO

conclusionsAerobic training at the dose and schedule tested is safe but not feasible for a significant proportion of patients with metastatic breast cancer. The acceptable feasibility and promising benefit for select patients warrant further evaluation in a dose-finding phase 1/2 study. Cancer 2018;124:2552-60. © 2018 American Cancer Society.

Indexed as

Patient Reported Outcome MeasuresQuality of LifeAdultAgedBreast NeoplasmsExerciseExercise TherapyFeasibility StudiesFemaleHumansMiddle AgedOxygen ConsumptionTreatment OutcomeYoung Adultcardiorespiratory fitnessdose modificationexercisepatient-reported outcomerelative dose intensity

Identifiers

PMID29624641
PMCPMC5990447

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.