Evidence map›Paper›PMID 29624170›Full record

ArticleeLife2018

Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock.

Laura Lleras Forero, Rachna Narayanan, Leonie Fa Huitema, Maaike VanBergen, Alexander Apschner, Josi Peterson-Maduro, Ive Logister, Guillaume Valentin, Luis G Morelli, Andrew C Oates and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 90 citations in OpenAlex.

  1. Review
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  13. Oscillatory control of embryonic development.Development (Cambridge, England) · 2024
    Review
  14. Review
  15. Science advances · 2024
    Article
  16. A Zebrafish Mutant in the Extracellular Matrix Protein GeneAnimals : an open access journal from MDPI · 2023
    Article
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  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 5 countries.

Laura Lleras ForeroInstitute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU Münster, Münster, Germany.
Rachna NarayananThe Francis Crick Institute, London, United Kingdom.
Leonie Fa HuitemaHubrecht Institute-KNAW & UMC Utrecht, Utrecht, Netherlands.
Maaike VanBergenInstitute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU Münster, Münster, Germany.
Alexander ApschnerHubrecht Institute-KNAW & UMC Utrecht, Utrecht, Netherlands.
Josi Peterson-MaduroHubrecht Institute-KNAW & UMC Utrecht, Utrecht, Netherlands.
Ive LogisterHubrecht Institute-KNAW & UMC Utrecht, Utrecht, Netherlands.
Guillaume ValentinThe Francis Crick Institute, London, United Kingdom.
Luis G Morelli *Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA), CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina.ORCID http://orcid.org/0000-0001-5614-073X
Andrew C Oates *The Francis Crick Institute, London, United Kingdom.ORCID http://orcid.org/0000-0002-3015-3978
Stefan Schulte-Merker *Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-3617-8807
University Medical Center Utrecht · NLThe Francis Crick Institute · GBMax Planck Institute of Molecular Physiology · DE

Funding

Cancer Research UKMedical Research Council MC_UP_1202/3Wellcome TrustWellcome Trust WT098025MA
6 · The paper itself

Abstract

Segmentation of the axial skeleton in amniotes depends on the segmentation clock, which patterns the paraxial mesoderm and the sclerotome. While the segmentation clock clearly operates in teleosts, the role of the sclerotome in establishing the axial skeleton is unclear. We severely disrupt zebrafish paraxial segmentation, yet observe a largely normal segmentation process of the chordacentra. We demonstrate that axial

Indexed as

Biological ClocksBody PatterningAnimalsAnimals, Genetically ModifiedBone and BonesEmbryo, NonmammalianGene Expression Regulation, DevelopmentalMesodermMutationNotochordPyrophosphatasesZebrafishZebrafish Proteinsentpd5a protein, zebrafishPyrophosphatasesZebrafish Proteinsdevelopmental biologyEntpd5notochordsomitesomitogenesis clockstem cellszebrafish

Identifiers

PMID29624170
PMCPMC5962341
OpenAlexW2795885538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.