Evidence map›Paper›PMID 29623956›Full record

ArticleCancer convergence2018

Cancer dormancy and criticality from a game theory perspective.

Amy Wu, David Liao, Vlamimir Kirilin, Ke-Chih Lin, Gonzalo Torga, Junle Qu, Liyu Liu, James C Sturm, Kenneth Pienta, Robert Austin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer convergence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Microenvironment-mediated cancer dormancy: Insights from metastability theory.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amy WuBanter AI, 408 Florence St., Palo Alto CA, 94301 USA.
David Liao2Department of Pathology, University of California at San Francisco, San Francisco, 94143 USA.
Vlamimir Kirilin3Department of Physics, Princeton University, Princeton, 08544 NJ USA.
Ke-Chih Lin4Department of Electrical Engineering, Princeton University, Princeton, 08544 USA.
Gonzalo Torga5The Johns Hopkins Hospital, 1800 Orleans St., Baltimore MD, 21287 USA.
Junle Qu6College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060 China.
Liyu Liu7College of Physics, Chongqing University, Chongqing China, 400044 China.
James C Sturm4Department of Electrical Engineering, Princeton University, Princeton, 08544 USA.
Kenneth Pienta5The Johns Hopkins Hospital, 1800 Orleans St., Baltimore MD, 21287 USA.
Robert Austin3Department of Physics, Princeton University, Princeton, 08544 NJ USA.ORCID 0000-0002-4269-6793

Funding

Tumor microvesicle-mediated modulation of the bone microenvironmentP01CA093900 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PIENTA, KENNETH J. · 2004 to 2024
$29.6M
TRANS_NETWORK PROJECTSU54CA143803 · NCI · PRINCETON UNIVERSITY · PI AUSTIN, ROBERT H. · 2009 to 2013
$14.2M
Mechanisms That Regulate Dormancy of Disseminated Tumor Cells in the Bone MarrowU54CA163124 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHIOZAWA, YUSUKE · 2011 to 2015
$3.0M
Reactive Stroma and Tumor Associated Macrophages in Prostate Cancer ProgressionU01CA143055 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PIENTA, KENNETH J., ROWLEY, DAVID R · 2010 to 2014
$2.7M
Spatiotemporal Regulation of Chk1 in Cell Biology, Cancer Etiology and TherapyR01CA163214 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI ZHANG, YOU-WEI · 2012 to 2016
$1.6M
NCI NIH HHS P01 CA093900NCI NIH HHS R01 CA163214NCI NIH HHS U01 CA143055NCI NIH HHS U54 CA143803NCI NIH HHS U54 CA163124
6 · The paper itself

Abstract

backgroundThe physics of cancer dormancy, the time between initial cancer treatment and re-emergence after a protracted period, is a puzzle. Cancer cells interact with host cells via complex, non-linear population dynamics, which can lead to very non-intuitive but perhaps deterministic and understandable progression dynamics of cancer and dormancy.

resultsWe explore here the dynamics of host-cancer cell populations in the presence of (1) payoffs gradients and (2) perturbations due to cell migration.

conclusionsWe determine to what extent the time-dependence of the populations can be quantitively understood in spite of the underlying complexity of the individual agents and model the phenomena of dormancy.

Indexed as

CancerDormancyGame theoryPerturbationsSimulation

Identifiers

PMID29623956
PMCPMC5876693

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.